MacLaren RE - Search Results

1

Structural Insights into the Unique Activation Mechanisms of a Non-classical Calpain and Its Disease-Causing Variants.

Velez G, Sun YJ, Khan S, Yang J, Herrmann J, Chemudupati T, MacLaren RE, Gakhar L, Wakatsuki S, Bassuk AG, Mahajan VB. Velez G, et al. Among authors: maclaren re. Cell Rep. 2020 Jan 21;30(3):881-892.e5. doi: 10.1016/j.celrep.2019.12.077. Cell Rep. 2020. PMID: 31968260 Free PMC article.

2

Two Novel CAPN5 Variants Associated with Mild and Severe Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy Phenotypes.

Randazzo NM MBBCh, BSc(Hons), Shanks ME PhD, Clouston P PhD, FRCPath, MacLaren RE MB ChB, DPhil, FRCOphth. Randazzo NM MBBCh, BSc(Hons), et al. Ocul Immunol Inflamm. 2019;27(5):693-698. doi: 10.1080/09273948.2017.1370651. Epub 2017 Oct 17. Ocul Immunol Inflamm. 2019. PMID: 29040051 Free PMC article.

3

Hypotrichosis and juvenile macular dystrophy caused by CDH3 mutation: A candidate disease for retinal gene therapy.

Singh MS, Broadgate S, Mathur R, Holt R, Halford S, MacLaren RE. Singh MS, et al. Among authors: maclaren re. Sci Rep. 2016 May 9;6:23674. doi: 10.1038/srep23674. Sci Rep. 2016. PMID: 27157923 Free PMC article.

4

Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice.

Barnea-Cramer AO, Wang W, Lu SJ, Singh MS, Luo C, Huo H, McClements ME, Barnard AR, MacLaren RE, Lanza R. Barnea-Cramer AO, et al. Among authors: maclaren re. Sci Rep. 2016 Jul 13;6:29784. doi: 10.1038/srep29784. Sci Rep. 2016. PMID: 27405580 Free PMC article.

5

Choroideremia: molecular mechanisms and development of AAV gene therapy.

Patrício MI, Barnard AR, Xue K, MacLaren RE. Patrício MI, et al. Among authors: maclaren re. Expert Opin Biol Ther. 2018 Jul;18(7):807-820. doi: 10.1080/14712598.2018.1484448. Epub 2018 Jun 22. Expert Opin Biol Ther. 2018. PMID: 29932012 Review.

6

Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival.

West EL, Pearson RA, Duran Y, Gonzalez-Cordero A, MacLaren RE, Smith AJ, Sowden JC, Ali RR. West EL, et al. Among authors: maclaren re. Cell Transplant. 2012;21(5):871-87. doi: 10.3727/096368911X623871. Epub 2012 Feb 2. Cell Transplant. 2012. PMID: 22325046 Free PMC article.

7

CRISPR Interference-Potential Application in Retinal Disease.

Peddle CF, Fry LE, McClements ME, MacLaren RE. Peddle CF, et al. Among authors: maclaren re. Int J Mol Sci. 2020 Mar 27;21(7):2329. doi: 10.3390/ijms21072329. Int J Mol Sci. 2020. PMID: 32230903 Free PMC article. Review.

8

Effect of AAV-Mediated Rhodopsin Gene Augmentation on Retinal Degeneration Caused by the Dominant P23H Rhodopsin Mutation in a Knock-In Murine Model.

Orlans HO, Barnard AR, Patrício MI, McClements ME, MacLaren RE. Orlans HO, et al. Among authors: maclaren re. Hum Gene Ther. 2020 Jul;31(13-14):730-742. doi: 10.1089/hum.2020.008. Epub 2020 Jun 26. Hum Gene Ther. 2020. PMID: 32394751

9

CRISPR-Cas9 DNA Base-Editing and Prime-Editing.

Kantor A, McClements ME, MacLaren RE. Kantor A, et al. Among authors: maclaren re. Int J Mol Sci. 2020 Aug 28;21(17):6240. doi: 10.3390/ijms21176240. Int J Mol Sci. 2020. PMID: 32872311 Free PMC article. Review.

10

Genetic and Clinical Findings in an Ethnically Diverse Cohort with Retinitis Pigmentosa Associated with Pathogenic Variants in CERKL.

Downes SM, Nguyen T, Tai V, Broadgate S, Shah M, Al-Khuzaei S, MacLaren RE, Shanks M, Clouston P, Halford S. Downes SM, et al. Among authors: maclaren re. Genes (Basel). 2020 Dec 12;11(12):1497. doi: 10.3390/genes11121497. Genes (Basel). 2020. PMID: 33322828 Free PMC article. Clinical Trial.

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