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Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
Toepfer CN, Garfinkel AC, Venturini G, Wakimoto H, Repetti G, Alamo L, Sharma A, Agarwal R, Ewoldt JK, Cloonan P, Letendre J, Lun M, Olivotto I, Colan S, Ashley E, Jacoby D, Michels M, Redwood CS, Watkins HC, Day SM, Staples JF, Padrón R, Chopra A, Ho CY, Chen CS, Pereira AC, Seidman JG, Seidman CE. Toepfer CN, et al. Among authors: chopra a. Circulation. 2020 Mar 10;141(10):828-842. doi: 10.1161/CIRCULATIONAHA.119.042339. Epub 2020 Jan 27. Circulation. 2020. PMID: 31983222 Free PMC article.
SarcTrack.
Toepfer CN, Sharma A, Cicconet M, Garfinkel AC, Mücke M, Neyazi M, Willcox JAL, Agarwal R, Schmid M, Rao J, Ewoldt J, Pourquié O, Chopra A, Chen CS, Seidman JG, Seidman CE. Toepfer CN, et al. Among authors: chopra a. Circ Res. 2019 Apr 12;124(8):1172-1183. doi: 10.1161/CIRCRESAHA.118.314505. Circ Res. 2019. PMID: 30700234 Free PMC article.
Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation.
Agarwal R, Paulo JA, Toepfer CN, Ewoldt JK, Sundaram S, Chopra A, Zhang Q, Gorham J, DePalma SR, Chen CS, Gygi SP, Seidman CE, Seidman JG. Agarwal R, et al. Among authors: chopra a. Circ Res. 2021 Sep 17;129(7):751-766. doi: 10.1161/CIRCRESAHA.120.317076. Epub 2021 Aug 18. Circ Res. 2021. PMID: 34405687 Free PMC article.
HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.
Hinson JT, Chopra A, Nafissi N, Polacheck WJ, Benson CC, Swist S, Gorham J, Yang L, Schafer S, Sheng CC, Haghighi A, Homsy J, Hubner N, Church G, Cook SA, Linke WA, Chen CS, Seidman JG, Seidman CE. Hinson JT, et al. Among authors: chopra a. Science. 2015 Aug 28;349(6251):982-6. doi: 10.1126/science.aaa5458. Science. 2015. PMID: 26315439 Free PMC article.
Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.
Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, Seidman JG, Seidman CE. Hinson JT, et al. Among authors: chopra a. Cell Rep. 2016 Dec 20;17(12):3292-3304. doi: 10.1016/j.celrep.2016.11.066. Cell Rep. 2016. PMID: 28009297 Free PMC article.
Probing the subcellular nanostructure of engineered human cardiomyocytes in 3D tissue.
Javor J, Ewoldt JK, Cloonan PE, Chopra A, Luu RJ, Freychet G, Zhernenkov M, Ludwig K, Seidman JG, Seidman CE, Chen CS, Bishop DJ. Javor J, et al. Among authors: chopra a. Microsyst Nanoeng. 2021 Jan 27;7:10. doi: 10.1038/s41378-020-00234-x. eCollection 2021. Microsyst Nanoeng. 2021. PMID: 34567727 Free PMC article.
Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs.
Chen G, Li S, Karakikes I, Ren L, Chow MZ, Chopra A, Keung W, Yan B, Chan CW, Costa KD, Kong CW, Hajjar RJ, Chen CS, Li RA. Chen G, et al. Among authors: chopra a. Circ Arrhythm Electrophysiol. 2015 Feb;8(1):193-202. doi: 10.1161/CIRCEP.114.002049. Epub 2014 Dec 10. Circ Arrhythm Electrophysiol. 2015. PMID: 25504561 Free PMC article.
Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation.
Poon E, Keung W, Liang Y, Ramalingam R, Yan B, Zhang S, Chopra A, Moore J, Herren A, Lieu DK, Wong HS, Weng Z, Wong OT, Lam YW, Tomaselli GF, Chen C, Boheler KR, Li RA. Poon E, et al. Among authors: chopra a. Circ Cardiovasc Genet. 2015 Jun;8(3):427-36. doi: 10.1161/CIRCGENETICS.114.000918. Epub 2015 Mar 10. Circ Cardiovasc Genet. 2015. PMID: 25759434
Force measurement tools to explore cadherin mechanotransduction.
Stapleton SC, Chopra A, Chen CS. Stapleton SC, et al. Among authors: chopra a. Cell Commun Adhes. 2014 Jun;21(3):193-205. doi: 10.3109/15419061.2014.905929. Epub 2014 Apr 23. Cell Commun Adhes. 2014. PMID: 24754475 Free PMC article. Review.
1,650 results