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Robotic fluidic coupling and interrogation of multiple vascularized organ chips.
Novak R, Ingram M, Marquez S, Das D, Delahanty A, Herland A, Maoz BM, Jeanty SSF, Somayaji MR, Burt M, Calamari E, Chalkiadaki A, Cho A, Choe Y, Chou DB, Cronce M, Dauth S, Divic T, Fernandez-Alcon J, Ferrante T, Ferrier J, FitzGerald EA, Fleming R, Jalili-Firoozinezhad S, Grevesse T, Goss JA, Hamkins-Indik T, Henry O, Hinojosa C, Huffstater T, Jang KJ, Kujala V, Leng L, Mannix R, Milton Y, Nawroth J, Nestor BA, Ng CF, O'Connor B, Park TE, Sanchez H, Sliz J, Sontheimer-Phelps A, Swenor B, Thompson G 2nd, Touloumes GJ, Tranchemontagne Z, Wen N, Yadid M, Bahinski A, Hamilton GA, Levner D, Levy O, Przekwas A, Prantil-Baun R, Parker KK, Ingber DE. Novak R, et al. Among authors: herland a. Nat Biomed Eng. 2020 Apr;4(4):407-420. doi: 10.1038/s41551-019-0497-x. Epub 2020 Jan 27. Nat Biomed Eng. 2020. PMID: 31988458 Free PMC article.
Engineered in vitro disease models.
Benam KH, Dauth S, Hassell B, Herland A, Jain A, Jang KJ, Karalis K, Kim HJ, MacQueen L, Mahmoodian R, Musah S, Torisawa YS, van der Meer AD, Villenave R, Yadid M, Parker KK, Ingber DE. Benam KH, et al. Among authors: herland a. Annu Rev Pathol. 2015;10:195-262. doi: 10.1146/annurev-pathol-012414-040418. Annu Rev Pathol. 2015. PMID: 25621660 Review.
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells.
Maoz BM, Herland A, FitzGerald EA, Grevesse T, Vidoudez C, Pacheco AR, Sheehy SP, Park TE, Dauth S, Mannix R, Budnik N, Shores K, Cho A, Nawroth JC, Segrè D, Budnik B, Ingber DE, Parker KK. Maoz BM, et al. Among authors: herland a. Nat Biotechnol. 2018 Oct;36(9):865-874. doi: 10.1038/nbt.4226. Epub 2018 Aug 20. Nat Biotechnol. 2018. PMID: 30125269 Free PMC article.
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies.
Park TE, Mustafaoglu N, Herland A, Hasselkus R, Mannix R, FitzGerald EA, Prantil-Baun R, Watters A, Henry O, Benz M, Sanchez H, McCrea HJ, Goumnerova LC, Song HW, Palecek SP, Shusta E, Ingber DE. Park TE, et al. Among authors: herland a. Nat Commun. 2019 Jun 13;10(1):2621. doi: 10.1038/s41467-019-10588-0. Nat Commun. 2019. PMID: 31197168 Free PMC article.
Reproducing human and cross-species drug toxicities using a Liver-Chip.
Jang KJ, Otieno MA, Ronxhi J, Lim HK, Ewart L, Kodella KR, Petropolis DB, Kulkarni G, Rubins JE, Conegliano D, Nawroth J, Simic D, Lam W, Singer M, Barale E, Singh B, Sonee M, Streeter AJ, Manthey C, Jones B, Srivastava A, Andersson LC, Williams D, Park H, Barrile R, Sliz J, Herland A, Haney S, Karalis K, Ingber DE, Hamilton GA. Jang KJ, et al. Among authors: herland a. Sci Transl Med. 2019 Nov 6;11(517):eaax5516. doi: 10.1126/scitranslmed.aax5516. Sci Transl Med. 2019. PMID: 31694927
Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips.
Herland A, Maoz BM, Das D, Somayaji MR, Prantil-Baun R, Novak R, Cronce M, Huffstater T, Jeanty SSF, Ingram M, Chalkiadaki A, Benson Chou D, Marquez S, Delahanty A, Jalili-Firoozinezhad S, Milton Y, Sontheimer-Phelps A, Swenor B, Levy O, Parker KK, Przekwas A, Ingber DE. Herland A, et al. Nat Biomed Eng. 2020 Apr;4(4):421-436. doi: 10.1038/s41551-019-0498-9. Epub 2020 Jan 27. Nat Biomed Eng. 2020. PMID: 31988459 Free PMC article.
74 results