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APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid.
Zhao N, Attrebi ON, Ren Y, Qiao W, Sonustun B, Martens YA, Meneses AD, Li F, Shue F, Zheng J, Van Ingelgom AJ, Davis MD, Kurti A, Knight JA, Linares C, Chen Y, Delenclos M, Liu CC, Fryer JD, Asmann YW, McLean PJ, Dickson DW, Ross OA, Bu G. Zhao N, et al. Among authors: zheng j. Sci Transl Med. 2020 Feb 5;12(529):eaay1809. doi: 10.1126/scitranslmed.aay1809. Sci Transl Med. 2020. PMID: 32024798 Free PMC article.
Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.
Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton LM, Mahmoudiandehkordi S, Kueider-Paisley A, Sonoustoun B, Arnold M, Shue F, Zheng J, Attrebi ON, Martens YA, Li Z, Bastea L, Meneses AD, Chen K, Thompson JW, St John-Williams L, Tachibana M, Aikawa T, Oue H, Job L, Yamazaki A, Liu CC, Storz P, Asmann YW, Ertekin-Taner N, Kanekiyo T, Kaddurah-Daouk R, Bu G. Zhao N, et al. Among authors: zheng j. Neuron. 2020 Jun 3;106(5):727-742.e6. doi: 10.1016/j.neuron.2020.02.034. Epub 2020 Mar 20. Neuron. 2020. PMID: 32199103 Free PMC article.
Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia.
Zhao N, Qiao W, Li F, Ren Y, Zheng J, Martens YA, Wang X, Li L, Liu CC, Chen K, Zhu Y, Ikezu TC, Li Z, Meneses AD, Jin Y, Knight JA, Chen Y, Bastea L, Linares C, Sonustun B, Job L, Smith ML, Xie M, Liu YU, Umpierre AD, Haruwaka K, Quicksall ZS, Storz P, Asmann YW, Wu LJ, Bu G. Zhao N, et al. Among authors: zheng j. J Exp Med. 2022 Dec 5;219(12):e20212479. doi: 10.1084/jem.20212479. Epub 2022 Sep 15. J Exp Med. 2022. PMID: 36107206 Free PMC article.
TREM2 mediates MHCII-associated CD4+ T cell response against gliomas.
Zheng J, Wang L, Zhao S, Zhang W, Chang Y, Dheer A, Gao S, Xu S, Ayasoufi K, Al-Kharboosh R, Xie M, Johnson AJ, Dong H, Quiñones-Hinojosa A, Wu LJ. Zheng J, et al. bioRxiv [Preprint]. 2023 Apr 6:2023.04.05.535697. doi: 10.1101/2023.04.05.535697. bioRxiv. 2023. PMID: 37066234 Free PMC article. Updated. Preprint.
Chemogenetic approaches reveal dual functions of microglia in seizures.
Dheer A, Bosco DB, Zheng J, Wang L, Zhao S, Haruwaka K, Yi MH, Barath A, Tian DS, Wu LJ. Dheer A, et al. Among authors: zheng j. Brain Behav Immun. 2024 Jan;115:406-418. doi: 10.1016/j.bbi.2023.11.002. Epub 2023 Nov 4. Brain Behav Immun. 2024. PMID: 37926132
Discrete class I molecules on brain endothelium differentially regulate neuropathology in experimental cerebral malaria.
Fain CE, Zheng J, Jin F, Ayasoufi K, Wu Y, Lilley MT, Dropik AR, Wolf DM, Rodriguez RC, Aibaidula A, Tritz ZP, Bouchal SM, Pewe LL, Urban SL, Chen Y, Chang SY, Hansen MJ, Kachergus JM, Shi J, Thompson EA, Jensen HE, Harty JT, Parney IF, Sun J, Wu LJ, Johnson AJ. Fain CE, et al. Among authors: zheng j. Brain. 2024 Feb 1;147(2):566-589. doi: 10.1093/brain/awad319. Brain. 2024. PMID: 37776513
TREM2 mediates MHCII-associated CD4+ T-cell response against gliomas.
Zheng J, Wang L, Zhao S, Zhang W, Chang Y, Bosco DB, Huang T, Dheer A, Gao S, Xu S, Ayasoufi K, Al-Kharboosh R, Qi F, Xie M, Johnson AJ, Dong H, Quiñones-Hinojosa A, Wu LJ. Zheng J, et al. Neuro Oncol. 2024 May 3;26(5):811-825. doi: 10.1093/neuonc/noad214. Neuro Oncol. 2024. PMID: 37941134
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