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An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia.
Johansen CT, Wang J, Lanktree MB, McIntyre AD, Ban MR, Martins RA, Kennedy BA, Hassell RG, Visser ME, Schwartz SM, Voight BF, Elosua R, Salomaa V, O'Donnell CJ, Dallinga-Thie GM, Anand SS, Yusuf S, Huff MW, Kathiresan S, Cao H, Hegele RA. Johansen CT, et al. Among authors: wang j. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1916-26. doi: 10.1161/ATVBAHA.111.226365. Epub 2011 May 19. Arterioscler Thromb Vasc Biol. 2011. PMID: 21597005 Free PMC article.
Targeted next-generation sequencing in monogenic dyslipidemias.
Hegele RA, Ban MR, Cao H, McIntyre AD, Robinson JF, Wang J. Hegele RA, et al. Among authors: wang j. Curr Opin Lipidol. 2015 Apr;26(2):103-13. doi: 10.1097/MOL.0000000000000163. Curr Opin Lipidol. 2015. PMID: 25692347 Review.
Polygenic Versus Monogenic Causes of Hypercholesterolemia Ascertained Clinically.
Wang J, Dron JS, Ban MR, Robinson JF, McIntyre AD, Alazzam M, Zhao PJ, Dilliott AA, Cao H, Huff MW, Rhainds D, Low-Kam C, Dubé MP, Lettre G, Tardif JC, Hegele RA. Wang J, et al. Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2439-2445. doi: 10.1161/ATVBAHA.116.308027. Epub 2016 Oct 20. Arterioscler Thromb Vasc Biol. 2016. PMID: 27765764
Polygenic determinants in extremes of high-density lipoprotein cholesterol.
Dron JS, Wang J, Low-Kam C, Khetarpal SA, Robinson JF, McIntyre AD, Ban MR, Cao H, Rhainds D, Dubé MP, Rader DJ, Lettre G, Tardif JC, Hegele RA. Dron JS, et al. Among authors: wang j. J Lipid Res. 2017 Nov;58(11):2162-2170. doi: 10.1194/jlr.M079822. Epub 2017 Sep 4. J Lipid Res. 2017. PMID: 28870971 Free PMC article.
Large-scale deletions of the ABCA1 gene in patients with hypoalphalipoproteinemia.
Dron JS, Wang J, Berberich AJ, Iacocca MA, Cao H, Yang P, Knoll J, Tremblay K, Brisson D, Netzer C, Gouni-Berthold I, Gaudet D, Hegele RA. Dron JS, et al. Among authors: wang j. J Lipid Res. 2018 Aug;59(8):1529-1535. doi: 10.1194/jlr.P086280. Epub 2018 Jun 4. J Lipid Res. 2018. PMID: 29866657 Free PMC article.
Severe hypertriglyceridemia is primarily polygenic.
Dron JS, Wang J, Cao H, McIntyre AD, Iacocca MA, Menard JR, Movsesyan I, Malloy MJ, Pullinger CR, Kane JP, Hegele RA. Dron JS, et al. Among authors: wang j. J Clin Lipidol. 2019 Jan-Feb;13(1):80-88. doi: 10.1016/j.jacl.2018.10.006. Epub 2018 Oct 24. J Clin Lipidol. 2019. PMID: 30466821 Free article.
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