Mohamed MF - Search Results

1

Efficacy and Safety of Upadacitinib in a Randomized Trial of Patients With Crohn's Disease.

Sandborn WJ, Feagan BG, Loftus EV Jr, Peyrin-Biroulet L, Van Assche G, D'Haens G, Schreiber S, Colombel JF, Lewis JD, Ghosh S, Armuzzi A, Scherl E, Herfarth H, Vitale L, Mohamed MF, Othman AA, Zhou Q, Huang B, Thakkar RB, Pangan AL, Lacerda AP, Panes J. Sandborn WJ, et al. Among authors: mohamed mf. Gastroenterology. 2020 Jun;158(8):2123-2138.e8. doi: 10.1053/j.gastro.2020.01.047. Epub 2020 Feb 8. Gastroenterology. 2020. PMID: 32044319 Free article. Clinical Trial.

2

Pharmacokinetics, Safety and Tolerability of ABT-494, a Novel Selective JAK 1 Inhibitor, in Healthy Volunteers and Subjects with Rheumatoid Arthritis.

Mohamed MF, Camp HS, Jiang P, Padley RJ, Asatryan A, Othman AA. Mohamed MF, et al. Clin Pharmacokinet. 2016 Dec;55(12):1547-1558. doi: 10.1007/s40262-016-0419-y. Clin Pharmacokinet. 2016. PMID: 27272171 Clinical Trial.

3

Assessment of effect of CYP3A inhibition, CYP induction, OATP1B inhibition, and high-fat meal on pharmacokinetics of the JAK1 inhibitor upadacitinib.

Mohamed MF, Jungerwirth S, Asatryan A, Jiang P, Othman AA. Mohamed MF, et al. Br J Clin Pharmacol. 2017 Oct;83(10):2242-2248. doi: 10.1111/bcp.13329. Epub 2017 Jun 19. Br J Clin Pharmacol. 2017. PMID: 28503781 Free PMC article. Clinical Trial.

4

Use of Early Clinical Trial Data to Support Thorough QT Study Waiver for Upadacitinib and Utility of Food Effect to Demonstrate ECG Assay Sensitivity.

Mohamed MF, Zeng J, Jiang P, Hosmane B, Othman AA. Mohamed MF, et al. Clin Pharmacol Ther. 2018 May;103(5):836-842. doi: 10.1002/cpt.804. Epub 2017 Sep 25. Clin Pharmacol Ther. 2018. PMID: 28762476 Free PMC article. Clinical Trial.

5

Population Pharmacokinetics of Upadacitinib in Healthy Subjects and Subjects with Rheumatoid Arthritis: Analyses of Phase I and II Clinical Trials.

Klünder B, Mohamed MF, Othman AA. Klünder B, et al. Among authors: mohamed mf. Clin Pharmacokinet. 2018 Aug;57(8):977-988. doi: 10.1007/s40262-017-0605-6. Clin Pharmacokinet. 2018. PMID: 29076110 Free PMC article. Review.

6

Pharmacokinetics of Upadacitinib With the Clinical Regimens of the Extended-Release Formulation Utilized in Rheumatoid Arthritis Phase 3 Trials.

Mohamed MF, Zeng J, Marroum PJ, Song IH, Othman AA. Mohamed MF, et al. Clin Pharmacol Drug Dev. 2019 Feb;8(2):208-216. doi: 10.1002/cpdd.462. Epub 2018 Apr 24. Clin Pharmacol Drug Dev. 2019. PMID: 29688617 Free PMC article. Clinical Trial.

7

Safety and efficacy of upadacitinib in patients with active rheumatoid arthritis refractory to biologic disease-modifying anti-rheumatic drugs (SELECT-BEYOND): a double-blind, randomised controlled phase 3 trial.

Genovese MC, Fleischmann R, Combe B, Hall S, Rubbert-Roth A, Zhang Y, Zhou Y, Mohamed MF, Meerwein S, Pangan AL. Genovese MC, et al. Among authors: mohamed mf. Lancet. 2018 Jun 23;391(10139):2513-2524. doi: 10.1016/S0140-6736(18)31116-4. Epub 2018 Jun 18. Lancet. 2018. PMID: 29908670 Clinical Trial.

8

The JAK1 Inhibitor Upadacitinib Has No Effect on the Pharmacokinetics of Levonorgestrel and Ethinylestradiol: A Study in Healthy Female Subjects.

Mohamed MF, Trueman S, Feng T, Friedman A, Othman AA. Mohamed MF, et al. J Clin Pharmacol. 2019 Apr;59(4):510-516. doi: 10.1002/jcph.1350. Epub 2018 Nov 30. J Clin Pharmacol. 2019. PMID: 30500075 Free PMC article. Clinical Trial.

9

Characterization of the Effect of Renal Impairment on Upadacitinib Pharmacokinetics.

Mohamed MF, Trueman S, Feng T, Anderson J, Marbury TC, Othman AA. Mohamed MF, et al. J Clin Pharmacol. 2019 Jun;59(6):856-862. doi: 10.1002/jcph.1375. Epub 2019 Jan 11. J Clin Pharmacol. 2019. PMID: 30633369 Free PMC article.

10

Population Pharmacokinetics of Upadacitinib Using the Immediate-Release and Extended-Release Formulations in Healthy Subjects and Subjects with Rheumatoid Arthritis: Analyses of Phase I-III Clinical Trials.

Klünder B, Mittapalli RK, Mohamed MF, Friedel A, Noertersheuser P, Othman AA. Klünder B, et al. Among authors: mohamed mf. Clin Pharmacokinet. 2019 Aug;58(8):1045-1058. doi: 10.1007/s40262-019-00739-3. Clin Pharmacokinet. 2019. PMID: 30945116 Free PMC article. Clinical Trial.

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