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Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers.
Coussy F, El Botty R, Lavigne M, Gu C, Fuhrmann L, Briaux A, de Koning L, Dahmani A, Montaudon E, Morisset L, Huguet L, Sourd L, Painsec P, Chateau-Joubert S, Larcher T, Vacher S, Melaabi S, Salomon AV, Marangoni E, Bieche I. Coussy F, et al. Among authors: de koning l. J Hematol Oncol. 2020 Feb 22;13(1):13. doi: 10.1186/s13045-020-0846-y. J Hematol Oncol. 2020. PMID: 32087759 Free PMC article.
Polo-like kinase 1: a potential therapeutic option in combination with conventional chemotherapy for the management of patients with triple-negative breast cancer.
Maire V, Némati F, Richardson M, Vincent-Salomon A, Tesson B, Rigaill G, Gravier E, Marty-Prouvost B, De Koning L, Lang G, Gentien D, Dumont A, Barillot E, Marangoni E, Decaudin D, Roman-Roman S, Pierré A, Cruzalegui F, Depil S, Tucker GC, Dubois T. Maire V, et al. Among authors: de koning l. Cancer Res. 2013 Jan 15;73(2):813-23. doi: 10.1158/0008-5472.CAN-12-2633. Epub 2012 Nov 9. Cancer Res. 2013. PMID: 23144294
Patient-derived xenografts recapitulate molecular features of human uveal melanomas.
Laurent C, Gentien D, Piperno-Neumann S, Némati F, Nicolas A, Tesson B, Desjardins L, Mariani P, Rapinat A, Sastre-Garau X, Couturier J, Hupé P, de Koning L, Dubois T, Roman-Roman S, Stern MH, Barillot E, Harbour JW, Saule S, Decaudin D. Laurent C, et al. Among authors: de koning l. Mol Oncol. 2013 Jun;7(3):625-36. doi: 10.1016/j.molonc.2013.02.004. Epub 2013 Feb 26. Mol Oncol. 2013. PMID: 23478236 Free PMC article.
TIPIN depletion leads to apoptosis in breast cancer cells.
Baldeyron C, Brisson A, Tesson B, Némati F, Koundrioukoff S, Saliba E, De Koning L, Martel E, Ye M, Rigaill G, Meseure D, Nicolas A, Gentien D, Decaudin D, Debatisse M, Depil S, Cruzalegui F, Pierré A, Roman-Roman S, Tucker GC, Dubois T. Baldeyron C, et al. Among authors: de koning l. Mol Oncol. 2015 Oct;9(8):1580-98. doi: 10.1016/j.molonc.2015.04.010. Epub 2015 May 9. Mol Oncol. 2015. PMID: 26004086 Free PMC article.
AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin.
Couderc C, Boin A, Fuhrmann L, Vincent-Salomon A, Mandati V, Kieffer Y, Mechta-Grigoriou F, Del Maestro L, Chavrier P, Vallerand D, Brito I, Dubois T, De Koning L, Bouvard D, Louvard D, Gautreau A, Lallemand D. Couderc C, et al. Among authors: de koning l. Neoplasia. 2016 Jan;18(1):10-24. doi: 10.1016/j.neo.2015.11.010. Neoplasia. 2016. PMID: 26806348 Free PMC article.
Arpin downregulation in breast cancer is associated with poor prognosis.
Lomakina ME, Lallemand F, Vacher S, Molinie N, Dang I, Cacheux W, Chipysheva TA, Ermilova VD, de Koning L, Dubois T, Bièche I, Alexandrova AY, Gautreau A. Lomakina ME, et al. Among authors: de koning l. Br J Cancer. 2016 Mar 1;114(5):545-53. doi: 10.1038/bjc.2016.18. Epub 2016 Feb 11. Br J Cancer. 2016. PMID: 26867158 Free PMC article.
Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma.
Carita G, Frisch-Dit-Leitz E, Dahmani A, Raymondie C, Cassoux N, Piperno-Neumann S, Némati F, Laurent C, De Koning L, Halilovic E, Jeay S, Wylie A, Emery C, Roman-Roman S, Schoumacher M, Decaudin D. Carita G, et al. Among authors: de koning l. Oncotarget. 2016 Jun 7;7(23):33542-56. doi: 10.18632/oncotarget.9552. Oncotarget. 2016. PMID: 27507190 Free PMC article.
207 results