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Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.
Pleguezuelos-Manzano C, Puschhof J, Rosendahl Huber A, van Hoeck A, Wood HM, Nomburg J, Gurjao C, Manders F, Dalmasso G, Stege PB, Paganelli FL, Geurts MH, Beumer J, Mizutani T, Miao Y, van der Linden R, van der Elst S; Genomics England Research Consortium; Garcia KC, Top J, Willems RJL, Giannakis M, Bonnet R, Quirke P, Meyerson M, Cuppen E, van Boxtel R, Clevers H. Pleguezuelos-Manzano C, et al. Among authors: garcia kc. Nature. 2020 Apr;580(7802):269-273. doi: 10.1038/s41586-020-2080-8. Epub 2020 Feb 27. Nature. 2020. PMID: 32106218 Free PMC article.
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.
Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC. Janda CY, et al. Among authors: garcia kc. Nature. 2017 May 11;545(7653):234-237. doi: 10.1038/nature22306. Epub 2017 May 3. Nature. 2017. PMID: 28467818 Free PMC article.
Receptor subtype discrimination using extensive shape complementary designed interfaces.
Dang LT, Miao Y, Ha A, Yuki K, Park K, Janda CY, Jude KM, Mohan K, Ha N, Vallon M, Yuan J, Vilches-Moure JG, Kuo CJ, Garcia KC, Baker D. Dang LT, et al. Among authors: garcia kc. Nat Struct Mol Biol. 2019 Jun;26(6):407-414. doi: 10.1038/s41594-019-0224-z. Epub 2019 May 13. Nat Struct Mol Biol. 2019. PMID: 31086346 Free PMC article.
Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo.
Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC. Miao Y, et al. Among authors: garcia kc. Cell Stem Cell. 2020 Nov 5;27(5):840-851.e6. doi: 10.1016/j.stem.2020.07.020. Epub 2020 Aug 19. Cell Stem Cell. 2020. PMID: 32818433 Free PMC article.
Immune receptor inhibition through enforced phosphatase recruitment.
Fernandes RA, Su L, Nishiga Y, Ren J, Bhuiyan AM, Cheng N, Kuo CJ, Picton LK, Ohtsuki S, Majzner RG, Rietberg SP, Mackall CL, Yin Q, Ali LR, Yang X, Savvides CS, Sage J, Dougan M, Garcia KC. Fernandes RA, et al. Among authors: garcia kc. Nature. 2020 Oct;586(7831):779-784. doi: 10.1038/s41586-020-2851-2. Epub 2020 Oct 21. Nature. 2020. PMID: 33087934 Free PMC article.
298 results