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The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them.
Smith MT, Guyton KZ, Kleinstreuer N, Borrel A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson WH 3rd, Houck KA, Kane AB, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden M. Smith MT, et al. Among authors: fielden m. Cancer Epidemiol Biomarkers Prev. 2020 Oct;29(10):1887-1903. doi: 10.1158/1055-9965.EPI-19-1346. Epub 2020 Mar 9. Cancer Epidemiol Biomarkers Prev. 2020. PMID: 32152214 Free PMC article.
Modernizing Human Cancer Risk Assessment of Therapeutics.
Fielden MR, Ward LD, Minocherhomji S, Nioi P, Lebrec H, Jacobson-Kram D. Fielden MR, et al. Trends Pharmacol Sci. 2018 Mar;39(3):232-247. doi: 10.1016/j.tips.2017.11.005. Epub 2017 Dec 11. Trends Pharmacol Sci. 2018. PMID: 29242029 Review.
Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing.
Valentine CC 3rd, Young RR, Fielden MR, Kulkarni R, Williams LN, Li T, Minocherhomji S, Salk JJ. Valentine CC 3rd, et al. Among authors: fielden mr. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33414-33425. doi: 10.1073/pnas.2013724117. Epub 2020 Dec 14. Proc Natl Acad Sci U S A. 2020. PMID: 33318186 Free PMC article.
Development and evaluation of a genomic signature for the prediction and mechanistic assessment of nongenotoxic hepatocarcinogens in the rat.
Fielden MR, Adai A, Dunn RT 2nd, Olaharski A, Searfoss G, Sina J, Aubrecht J, Boitier E, Nioi P, Auerbach S, Jacobson-Kram D, Raghavan N, Yang Y, Kincaid A, Sherlock J, Chen SJ, Car B; Predictive Safety Testing Consortium, Carcinogenicity Working Group. Fielden MR, et al. Toxicol Sci. 2011 Nov;124(1):54-74. doi: 10.1093/toxsci/kfr202. Epub 2011 Aug 2. Toxicol Sci. 2011. PMID: 21813463
Although numerous short-term in vitro and in vivo assays have been developed, they have failed to reliably predict the carcinogenicity of nongenotoxic compounds. Extending upon previous microarray work (Fielden, M. R., Nie, A., McMillian, M., Elangbam, C. S., …
Although numerous short-term in vitro and in vivo assays have been developed, they have failed to reliably predict the carcinogenicity of no …
Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.
Fielden MR, Nie A, McMillian M, Elangbam CS, Trela BA, Yang Y, Dunn RT 2nd, Dragan Y, Fransson-Stehen R, Bogdanffy M, Adams SP, Foster WR, Chen SJ, Rossi P, Kasper P, Jacobson-Kram D, Tatsuoka KS, Wier PJ, Gollub J, Halbert DN, Roter A, Young JK, Sina JF, Marlowe J, Martus HJ, Aubrecht J, Olaharski AJ, Roome N, Nioi P, Pardo I, Snyder R, Perry R, Lord P, Mattes W, Car BD; Predictive Safety Testing Consortium; Carcinogenicity Working Group. Fielden MR, et al. Toxicol Sci. 2008 May;103(1):28-34. doi: 10.1093/toxsci/kfn022. Epub 2008 Feb 14. Toxicol Sci. 2008. PMID: 18281259
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