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An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci.
Logue MW, Miller MW, Wolf EJ, Huber BR, Morrison FG, Zhou Z, Zheng Y, Smith AK, Daskalakis NP, Ratanatharathorn A, Uddin M, Nievergelt CM, Ashley-Koch AE, Baker DG, Beckham JC, Garrett ME, Boks MP, Geuze E, Grant GA, Hauser MA, Kessler RC, Kimbrel NA, Maihofer AX, Marx CE, Qin XJ, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Ware EB, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Hayes JP, Verfaellie M; Traumatic Stress Brain Study Group. Logue MW, et al. Among authors: zheng y. Clin Epigenetics. 2020 Mar 14;12(1):46. doi: 10.1186/s13148-020-0820-0. Clin Epigenetics. 2020. PMID: 32171335 Free PMC article.
PTSD is associated with increased DNA methylation across regions of HLA-DPB1 and SPATC1L.
Katrinli S, Zheng Y, Gautam A, Hammamieh R, Yang R, Venkateswaran S, Kilaru V, Lori A, Hinrichs R, Powers A, Gillespie CF, Wingo AP, Michopoulos V, Jovanovic T, Wolf EJ, McGlinchey RE, Milberg WP, Miller MW, Kugathasan S, Jett M, Logue MW, Ressler KJ, Smith AK. Katrinli S, et al. Among authors: zheng y. Brain Behav Immun. 2021 Jan;91:429-436. doi: 10.1016/j.bbi.2020.10.023. Epub 2020 Nov 3. Brain Behav Immun. 2021. PMID: 33152445 Free PMC article.
Trauma and posttraumatic stress disorder modulate polygenic predictors of hippocampal and amygdala volume.
Zheng Y, Garrett ME, Sun D, Clarke-Rubright EK, Haswell CC, Maihofer AX, Elman JA, Franz CE, Lyons MJ, Kremen WS, Peverill M, Sambrook K, McLaughlin KA, Davenport ND, Disner S, Sponheim SR, Andrew E, Korgaonkar M, Bryant R, Varkevisser T, Geuze E, Coleman J, Beckham JC, Kimbrel NA, Sullivan D, Miller M, Hayes J, Verfaellie M, Wolf E, Salat D, Spielberg JM, Milberg W, McGlinchey R, Dennis EL, Thompson PM, Medland S, Jahanshad N, Nievergelt CM, Ashley-Koch AE, Logue MW, Morey RA. Zheng Y, et al. Transl Psychiatry. 2021 Dec 16;11(1):637. doi: 10.1038/s41398-021-01707-x. Transl Psychiatry. 2021. PMID: 34916497 Free PMC article.
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