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A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions.
Azimi I, Stevenson RJ, Zhang X, Meizoso-Huesca A, Xin P, Johnson M, Flanagan JU, Chalmers SB, Yoast RE, Kapure JS, Ross BP, Vetter I, Ashton MR, Launikonis BS, Denny WA, Trebak M, Monteith GR. Azimi I, et al. Among authors: launikonis bs. ACS Pharmacol Transl Sci. 2020 Feb 14;3(1):135-147. doi: 10.1021/acsptsci.9b00081. Epub 2020 Jan 13. ACS Pharmacol Transl Sci. 2020. PMID: 32190822 Free PMC article.
Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle.
Lamboley CR, Pearce L, Seng C, Meizoso-Huesca A, Singh DP, Frankish BP, Kaura V, Lo HP, Ferguson C, Allen PD, Hopkins PM, Parton RG, Murphy RM, van der Poel C, Barclay CJ, Launikonis BS. Lamboley CR, et al. Among authors: launikonis bs. Sci Adv. 2021 Oct 29;7(44):eabi7166. doi: 10.1126/sciadv.abi7166. Epub 2021 Oct 27. Sci Adv. 2021. PMID: 34705503 Free PMC article.
A bivalent remipede toxin promotes calcium release via ryanodine receptor activation.
Maxwell MJ, Thekkedam C, Lamboley C, Chin YK, Crawford T, Smith JJ, Liu J, Jia X, Vetter I, Laver DR, Launikonis BS, Dulhunty A, Undheim EAB, Mobli M. Maxwell MJ, et al. Among authors: launikonis bs. Nat Commun. 2023 Feb 23;14(1):1036. doi: 10.1038/s41467-023-36579-w. Nat Commun. 2023. PMID: 36823422 Free PMC article.
Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle.
Edwards JN, Friedrich O, Cully TR, von Wegner F, Murphy RM, Launikonis BS. Edwards JN, et al. Among authors: launikonis bs. Am J Physiol Cell Physiol. 2010 Jul;299(1):C42-50. doi: 10.1152/ajpcell.00524.2009. Epub 2010 Apr 28. Am J Physiol Cell Physiol. 2010. PMID: 20427714 Free article.
65 results