Stevenson RJ - Search Results

1

A new selective pharmacological enhancer of the Orai1 Ca²⁺ channel reveals roles for Orai1 in smooth and skeletal muscle functions.

Azimi I, Stevenson RJ, Zhang X, Meizoso-Huesca A, Xin P, Johnson M, Flanagan JU, Chalmers SB, Yoast RE, Kapure JS, Ross BP, Vetter I, Ashton MR, Launikonis BS, Denny WA, Trebak M, Monteith GR. Azimi I, et al. Among authors: stevenson rj. ACS Pharmacol Transl Sci. 2020 Feb 14;3(1):135-147. doi: 10.1021/acsptsci.9b00081. Epub 2020 Jan 13. ACS Pharmacol Transl Sci. 2020. PMID: 32190822 Free PMC article.

2

Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca²⁺ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay.

Azimi I, Flanagan JU, Stevenson RJ, Inserra M, Vetter I, Monteith GR, Denny WA. Azimi I, et al. Among authors: stevenson rj. Bioorg Med Chem. 2017 Jan 1;25(1):440-449. doi: 10.1016/j.bmc.2016.11.007. Epub 2016 Nov 7. Bioorg Med Chem. 2017. PMID: 27856238

3

An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca²⁺ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay.

Stevenson RJ, Azimi I, Flanagan JU, Inserra M, Vetter I, Monteith GR, Denny WA. Stevenson RJ, et al. Bioorg Med Chem. 2018 Jul 23;26(12):3406-3413. doi: 10.1016/j.bmc.2018.05.012. Epub 2018 May 9. Bioorg Med Chem. 2018. PMID: 29776832

4

Nitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapy.

Stevenson RJ, Denny WA, Tercel M, Pruijn FB, Ashoorzadeh A. Stevenson RJ, et al. J Med Chem. 2012 Mar 22;55(6):2780-802. doi: 10.1021/jm201717y. Epub 2012 Mar 2. J Med Chem. 2012. PMID: 22339090

5

The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycins.

Ashoorzadeh A, Atwell GJ, Pruijn FB, Wilson WR, Tercel M, Denny WA, Stevenson RJ. Ashoorzadeh A, et al. Among authors: stevenson rj. Bioorg Med Chem. 2011 Aug 15;19(16):4851-60. doi: 10.1016/j.bmc.2011.06.073. Epub 2011 Jun 29. Bioorg Med Chem. 2011. PMID: 21767954

6

Synthesis and evaluation of stable bidentate transition metal complexes of 1-(chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as hypoxia selective cytotoxins.

Milbank JB, Stevenson RJ, Ware DC, Chang JY, Tercel M, Ahn GO, Wilson WR, Denny WA. Milbank JB, et al. Among authors: stevenson rj. J Med Chem. 2009 Nov 12;52(21):6822-34. doi: 10.1021/jm9008746. J Med Chem. 2009. PMID: 19821576

7

The effect of a bromide leaving group on the properties of nitro analogs of the duocarmycins as hypoxia-activated prodrugs and phosphate pre-prodrugs for antitumor therapy.

Stevenson RJ, Denny WA, Ashoorzadeh A, Pruijn FB, van Leeuwen WF, Tercel M. Stevenson RJ, et al. Bioorg Med Chem. 2011 Oct 15;19(20):5989-98. doi: 10.1016/j.bmc.2011.08.045. Epub 2011 Aug 25. Bioorg Med Chem. 2011. PMID: 21920763

8

Syntheses of 8-quinolinolatocobalt(III) complexes containing cyclen based auxiliary ligands as models for hypoxia-activated prodrugs.

Chang JY, Stevenson RJ, Lu GL, Brothers PJ, Clark GR, Denny WA, Ware DC. Chang JY, et al. Among authors: stevenson rj. Dalton Trans. 2010 Dec 28;39(48):11535-50. doi: 10.1039/c0dt01142h. Epub 2010 Nov 22. Dalton Trans. 2010. PMID: 21103540

9

Hypoxia-activated prodrugs: substituent effects on the properties of nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) prodrugs of DNA minor groove alkylating agents.

Tercel M, Atwell GJ, Yang S, Stevenson RJ, Botting KJ, Boyd M, Smith E, Anderson RF, Denny WA, Wilson WR, Pruijn FB. Tercel M, et al. Among authors: stevenson rj. J Med Chem. 2009 Nov 26;52(22):7258-72. doi: 10.1021/jm901202b. J Med Chem. 2009. PMID: 19877646

10

N-alkylated cyclen cobalt(III) complexes of 1-(chloromethyl)-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugs.

Lu GL, Stevenson RJ, Chang JY, Brothers PJ, Ware DC, Wilson WR, Denny WA, Tercel M. Lu GL, et al. Among authors: stevenson rj. Bioorg Med Chem. 2011 Aug 15;19(16):4861-7. doi: 10.1016/j.bmc.2011.06.076. Epub 2011 Jul 1. Bioorg Med Chem. 2011. PMID: 21775153

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