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A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions.
Azimi I, Stevenson RJ, Zhang X, Meizoso-Huesca A, Xin P, Johnson M, Flanagan JU, Chalmers SB, Yoast RE, Kapure JS, Ross BP, Vetter I, Ashton MR, Launikonis BS, Denny WA, Trebak M, Monteith GR. Azimi I, et al. Among authors: zhang x. ACS Pharmacol Transl Sci. 2020 Feb 14;3(1):135-147. doi: 10.1021/acsptsci.9b00081. Epub 2020 Jan 13. ACS Pharmacol Transl Sci. 2020. PMID: 32190822 Free PMC article.
Airway smooth muscle STIM1 and Orai1 are upregulated in asthmatic mice and mediate PDGF-activated SOCE, CRAC currents, proliferation, and migration.
Spinelli AM, González-Cobos JC, Zhang X, Motiani RK, Rowan S, Zhang W, Garrett J, Vincent PA, Matrougui K, Singer HA, Trebak M. Spinelli AM, et al. Among authors: zhang w, zhang x. Pflugers Arch. 2012 Nov;464(5):481-92. doi: 10.1007/s00424-012-1160-5. Epub 2012 Sep 27. Pflugers Arch. 2012. PMID: 23014880 Free PMC article.
What role for store-operated Ca²⁺ entry in muscle?
Trebak M, Zhang W, Ruhle B, Henkel MM, González-Cobos JC, Motiani RK, Stolwijk JA, Newton RL, Zhang X. Trebak M, et al. Among authors: zhang w, zhang x. Microcirculation. 2013 May;20(4):330-6. doi: 10.1111/micc.12042. Microcirculation. 2013. PMID: 23312019 Free PMC article. Review.
Emerging roles of Orai3 in pathophysiology.
Motiani RK, Stolwijk JA, Newton RL, Zhang X, Trebak M. Motiani RK, et al. Among authors: zhang x. Channels (Austin). 2013 Sep-Oct;7(5):392-401. doi: 10.4161/chan.24960. Epub 2013 May 21. Channels (Austin). 2013. PMID: 23695829 Free PMC article. Review.
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