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Genome-scale CRISPR-Cas9 knockout screening in human cells.
Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F. Shalem O, et al. Science. 2014 Jan 3;343(6166):84-87. doi: 10.1126/science.1247005. Epub 2013 Dec 12. Science. 2014. PMID: 24336571 Free PMC article.
Genome-scale CRISPR pooled screens.
Sanjana NE. Sanjana NE. Anal Biochem. 2017 Sep 1;532:95-99. doi: 10.1016/j.ab.2016.05.014. Epub 2016 Jun 1. Anal Biochem. 2017. PMID: 27261176 Free PMC article.
A genome-wide net to catch and understand cancer.
Sanjana NE. Sanjana NE. Sci Transl Med. 2018 Aug 8;10(453):eaat8288. doi: 10.1126/scitranslmed.aat8288. Sci Transl Med. 2018. PMID: 30089637 Free PMC article. Review.
Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens.
Liscovitch-Brauer N, Montalbano A, Deng J, Méndez-Mancilla A, Wessels HH, Moss NG, Kung CY, Sookdeo A, Guo X, Geller E, Jaini S, Smibert P, Sanjana NE. Liscovitch-Brauer N, et al. Among authors: sanjana ne. Nat Biotechnol. 2021 Oct;39(10):1270-1277. doi: 10.1038/s41587-021-00902-x. Epub 2021 Apr 29. Nat Biotechnol. 2021. PMID: 33927415 Free PMC article.
CRISPR in cancer biology and therapy.
Katti A, Diaz BJ, Caragine CM, Sanjana NE, Dow LE. Katti A, et al. Nat Rev Cancer. 2022 May;22(5):259-279. doi: 10.1038/s41568-022-00441-w. Epub 2022 Feb 22. Nat Rev Cancer. 2022. PMID: 35194172 Review.
Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase.
Ferrarone JR, Thomas J, Unni AM, Zheng Y, Nagiec MJ, Gardner EE, Mashadova O, Li K, Koundouros N, Montalbano A, Mustafa M, Cantley LC, Blenis J, Sanjana NE, Varmus H. Ferrarone JR, et al. Among authors: sanjana ne. Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2403685121. doi: 10.1073/pnas.2403685121. Epub 2024 May 14. Proc Natl Acad Sci U S A. 2024. PMID: 38743625 Free PMC article.
80 results