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Poised epigenetic states and acquired drug resistance in cancer.
Brown R, Curry E, Magnani L, Wilhelm-Benartzi CS, Borley J. Brown R, et al. Among authors: magnani l. Nat Rev Cancer. 2014 Nov;14(11):747-53. doi: 10.1038/nrc3819. Epub 2014 Sep 25. Nat Rev Cancer. 2014. PMID: 25253389 Review.
Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion.
Nguyen VT, Barozzi I, Faronato M, Lombardo Y, Steel JH, Patel N, Darbre P, Castellano L, Győrffy B, Woodley L, Meira A, Patten DK, Vircillo V, Periyasamy M, Ali S, Frige G, Minucci S, Coombes RC, Magnani L. Nguyen VT, et al. Among authors: magnani l. Nat Commun. 2015 Nov 27;6:10044. doi: 10.1038/ncomms10044. Nat Commun. 2015. PMID: 26610607 Free PMC article.
Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer.
Patten DK, Corleone G, Győrffy B, Perone Y, Slaven N, Barozzi I, Erdős E, Saiakhova A, Goddard K, Vingiani A, Shousha S, Pongor LS, Hadjiminas DJ, Schiavon G, Barry P, Palmieri C, Coombes RC, Scacheri P, Pruneri G, Magnani L. Patten DK, et al. Among authors: magnani l. Nat Med. 2018 Sep;24(9):1469-1480. doi: 10.1038/s41591-018-0091-x. Epub 2018 Jul 23. Nat Med. 2018. PMID: 30038216 Free PMC article.
SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer.
Perone Y, Farrugia AJ, Rodríguez-Meira A, Győrffy B, Ion C, Uggetti A, Chronopoulos A, Marrazzo P, Faronato M, Shousha S, Davies C, Steel JH, Patel N, Del Rio Hernandez A, Coombes C, Pruneri G, Lim A, Calvo F, Magnani L. Perone Y, et al. Among authors: magnani l. Nat Commun. 2019 May 9;10(1):2115. doi: 10.1038/s41467-019-09676-y. Nat Commun. 2019. PMID: 31073170 Free PMC article.
Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy.
Hong SP, Chan TE, Lombardo Y, Corleone G, Rotmensz N, Bravaccini S, Rocca A, Pruneri G, McEwen KR, Coombes RC, Barozzi I, Magnani L. Hong SP, et al. Among authors: magnani l. Nat Commun. 2019 Sep 2;10(1):3840. doi: 10.1038/s41467-019-11721-9. Nat Commun. 2019. PMID: 31477698 Free PMC article.
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer.
Acar A, Nichol D, Fernandez-Mateos J, Cresswell GD, Barozzi I, Hong SP, Trahearn N, Spiteri I, Stubbs M, Burke R, Stewart A, Caravagna G, Werner B, Vlachogiannis G, Maley CC, Magnani L, Valeri N, Banerji U, Sottoriva A. Acar A, et al. Among authors: magnani l. Nat Commun. 2020 Apr 21;11(1):1923. doi: 10.1038/s41467-020-15596-z. Nat Commun. 2020. PMID: 32317663 Free PMC article.
The co-evolution of the genome and epigenome in colorectal cancer.
Heide T, Househam J, Cresswell GD, Spiteri I, Lynn C, Mossner M, Kimberley C, Fernandez-Mateos J, Chen B, Zapata L, James C, Barozzi I, Chkhaidze K, Nichol D, Gunasri V, Berner A, Schmidt M, Lakatos E, Baker AM, Costa H, Mitchinson M, Piazza R, Jansen M, Caravagna G, Ramazzotti D, Shibata D, Bridgewater J, Rodriguez-Justo M, Magnani L, Graham TA, Sottoriva A. Heide T, et al. Among authors: magnani l. Nature. 2022 Nov;611(7937):733-743. doi: 10.1038/s41586-022-05202-1. Epub 2022 Oct 26. Nature. 2022. PMID: 36289335 Free PMC article.
Phenotypic plasticity and genetic control in colorectal cancer evolution.
Househam J, Heide T, Cresswell GD, Spiteri I, Kimberley C, Zapata L, Lynn C, James C, Mossner M, Fernandez-Mateos J, Vinceti A, Baker AM, Gabbutt C, Berner A, Schmidt M, Chen B, Lakatos E, Gunasri V, Nichol D, Costa H, Mitchinson M, Ramazzotti D, Werner B, Iorio F, Jansen M, Caravagna G, Barnes CP, Shibata D, Bridgewater J, Rodriguez-Justo M, Magnani L, Sottoriva A, Graham TA. Househam J, et al. Among authors: magnani l. Nature. 2022 Nov;611(7937):744-753. doi: 10.1038/s41586-022-05311-x. Epub 2022 Oct 26. Nature. 2022. PMID: 36289336 Free PMC article.
Contribution of pks+ E. coli mutations to colorectal carcinogenesis.
Chen B, Ramazzotti D, Heide T, Spiteri I, Fernandez-Mateos J, James C, Magnani L, Graham TA, Sottoriva A. Chen B, et al. Among authors: magnani l. Nat Commun. 2023 Nov 29;14(1):7827. doi: 10.1038/s41467-023-43329-5. Nat Commun. 2023. PMID: 38030613 Free PMC article.
169 results