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The β-Secretase BACE1 in Alzheimer's Disease.
Hampel H, Vassar R, De Strooper B, Hardy J, Willem M, Singh N, Zhou J, Yan R, Vanmechelen E, De Vos A, Nisticò R, Corbo M, Imbimbo BP, Streffer J, Voytyuk I, Timmers M, Tahami Monfared AA, Irizarry M, Albala B, Koyama A, Watanabe N, Kimura T, Yarenis L, Lista S, Kramer L, Vergallo A. Hampel H, et al. Among authors: watanabe n. Biol Psychiatry. 2021 Apr 15;89(8):745-756. doi: 10.1016/j.biopsych.2020.02.001. Epub 2020 Feb 13. Biol Psychiatry. 2021. PMID: 32223911 Free PMC article. Review.
C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester).
Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T. Morohashi Y, et al. Among authors: watanabe n. J Biol Chem. 2006 May 26;281(21):14670-6. doi: 10.1074/jbc.M513012200. Epub 2006 Mar 28. J Biol Chem. 2006. PMID: 16569643 Free article.
Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.
Watanabe N, Image Image II, Takagi S, Image Image II, Tominaga A, Image Image I, Tomita T, Image Image II, Iwatsubo T, Image Image I. Watanabe N, et al. J Biol Chem. 2010 Jun 25;285(26):19738-46. doi: 10.1074/jbc.M110.101287. Epub 2010 Apr 23. J Biol Chem. 2010. PMID: 20418378 Free PMC article.
4,406 results