Dong Y - Search Results

1

Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67.

Alshammari AM, Smith DD, Parriott J, Stewart JP, Curran SM, McCulloh RJ, Barry PA, Iyer SS, Palermo N, Phillips JA, Dong Y, Ronning DR, Vennerstrom JL, Sanderson SD, Vetro JA. Alshammari AM, et al. Among authors: dong y. ACS Infect Dis. 2020 May 8;6(5):1169-1181. doi: 10.1021/acsinfecdis.0c00005. Epub 2020 Apr 13. ACS Infect Dis. 2020. PMID: 32233506 Free PMC article.

2

Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.

Dong Y, Matile H, Chollet J, Kaminsky R, Wood JK, Vennerstrom JL. Dong Y, et al. J Med Chem. 1999 Apr 22;42(8):1477-80. doi: 10.1021/jm980698f. J Med Chem. 1999. PMID: 10212135

3

Mechanisms of in situ activation for peroxidic antimalarials.

Dong Y, Vennerstrom JL. Dong Y, et al. Redox Rep. 2003;8(5):284-8. doi: 10.1179/135100003225002989. Redox Rep. 2003. PMID: 14962366 Review.

4

Synthetic peroxides as antimalarials.

Tang Y, Dong Y, Vennerstrom JL. Tang Y, et al. Among authors: dong y. Med Res Rev. 2004 Jul;24(4):425-48. doi: 10.1002/med.10066. Med Res Rev. 2004. PMID: 15170591 Review.

5

Identification of an antimalarial synthetic trioxolane drug development candidate.

Vennerstrom JL, Arbe-Barnes S, Brun R, Charman SA, Chiu FC, Chollet J, Dong Y, Dorn A, Hunziker D, Matile H, McIntosh K, Padmanilayam M, Santo Tomas J, Scheurer C, Scorneaux B, Tang Y, Urwyler H, Wittlin S, Charman WN. Vennerstrom JL, et al. Among authors: dong y. Nature. 2004 Aug 19;430(7002):900-4. doi: 10.1038/nature02779. Nature. 2004. PMID: 15318224 Free article.

6

Synthesis of tetrasubstituted ozonides by the Griesbaum coozonolysis reaction: diastereoselectivity and functional group transformations by post-ozonolysis reactions.

Tang Y, Dong Y, Karle JM, DiTusa CA, Vennerstrom JL. Tang Y, et al. Among authors: dong y. J Org Chem. 2004 Sep 17;69(19):6470-3. doi: 10.1021/jo040171c. J Org Chem. 2004. PMID: 15357611

7

Dispiro-1,2,4-trioxane analogues of a prototype dispiro-1,2,4-trioxolane: mechanistic comparators for artemisinin in the context of reaction pathways with iron(II).

Tang Y, Dong Y, Wang X, Sriraghavan K, Wood JK, Vennerstrom JL. Tang Y, et al. Among authors: dong y. J Org Chem. 2005 Jun 24;70(13):5103-10. doi: 10.1021/jo050385+. J Org Chem. 2005. PMID: 15960511

8

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

Dong Y, Chollet J, Matile H, Charman SA, Chiu FC, Charman WN, Scorneaux B, Urwyler H, Santo Tomas J, Scheurer C, Snyder C, Dorn A, Wang X, Karle JM, Tang Y, Wittlin S, Brun R, Vennerstrom JL. Dong Y, et al. J Med Chem. 2005 Jul 28;48(15):4953-61. doi: 10.1021/jm049040u. J Med Chem. 2005. PMID: 16033274

9

Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials.

Perry CS, Charman SA, Prankerd RJ, Chiu FC, Dong Y, Vennerstrom JL, Charman WN. Perry CS, et al. Among authors: dong y. J Pharm Sci. 2006 Apr;95(4):737-47. doi: 10.1002/jps.20568. J Pharm Sci. 2006. PMID: 16435367

10

Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes.

Dong Y, Tang Y, Chollet J, Matile H, Wittlin S, Charman SA, Charman WN, Tomas JS, Scheurer C, Snyder C, Scorneaux B, Bajpai S, Alexander SA, Wang X, Padmanilayam M, Cheruku SR, Brun R, Vennerstrom JL. Dong Y, et al. Bioorg Med Chem. 2006 Sep 15;14(18):6368-82. doi: 10.1016/j.bmc.2006.05.041. Epub 2006 Jun 8. Bioorg Med Chem. 2006. PMID: 16759871

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