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The Lacritin-Syndecan-1-Heparanase Axis in Dry Eye Disease.
Dias-Teixeira K, Horton X, McKown R, Romano J, Laurie GW. Dias-Teixeira K, et al. Among authors: mckown r. Adv Exp Med Biol. 2020;1221:747-757. doi: 10.1007/978-3-030-34521-1_31. Adv Exp Med Biol. 2020. PMID: 32274735 Free PMC article. Review.
Focus on molecules: lacritin.
Ma P, Wang N, McKown RL, Raab RW, Laurie GW. Ma P, et al. Exp Eye Res. 2008 Mar;86(3):457-8. doi: 10.1016/j.exer.2007.01.025. Epub 2007 Feb 16. Exp Eye Res. 2008. PMID: 17412322 Free PMC article. Review. No abstract available.
Lacritin and other new proteins of the lacrimal functional unit.
McKown RL, Wang N, Raab RW, Karnati R, Zhang Y, Williams PB, Laurie GW. McKown RL, et al. Exp Eye Res. 2009 May;88(5):848-58. doi: 10.1016/j.exer.2008.09.002. Epub 2008 Sep 18. Exp Eye Res. 2009. PMID: 18840430 Free PMC article. Review.
Focus on molecules: syndecan-1.
Zhang Y, McKown RL, Raab RW, Rapraeger AC, Laurie GW. Zhang Y, et al. Exp Eye Res. 2011 Oct;93(4):329-30. doi: 10.1016/j.exer.2010.06.008. Epub 2010 Jun 23. Exp Eye Res. 2011. PMID: 20599970 Free PMC article. No abstract available.
Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity.
Zhang Y, Wang N, Raab RW, McKown RL, Irwin JA, Kwon I, van Kuppevelt TH, Laurie GW. Zhang Y, et al. J Biol Chem. 2013 Apr 26;288(17):12090-101. doi: 10.1074/jbc.M112.422717. Epub 2013 Mar 15. J Biol Chem. 2013. PMID: 23504321 Free PMC article.
Nevertheless, heparanase deglycanation of the N-terminal HS-rich domain of syndecan-1 (SDC1), but not SDC2 or -4, is a prerequisite for binding of the prosecretory mitogen lacritin (Ma, P., Beck, S. L., Raab, R. W., McKown, R. L., Coffman, G. L., Utani, A., C …
Nevertheless, heparanase deglycanation of the N-terminal HS-rich domain of syndecan-1 (SDC1), but not SDC2 or -4, is a prerequisite for bind …
Development of a Quantitative Immunoassay for Tear Lacritin Proteoforms.
Justis BM, Coburn CE, Tyler EM, Showalter RS, Dissler BJ, Li M, McNamara NA, Laurie GW, McKown RL. Justis BM, et al. Among authors: mckown rl. Transl Vis Sci Technol. 2020 Aug 6;9(9):13. doi: 10.1167/tvst.9.9.13. eCollection 2020 Aug. Transl Vis Sci Technol. 2020. PMID: 32879769 Free PMC article.
Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis.
Georgiev GA, Gh MS, Romano J, Dias Teixeira KL, Struble C, Ryan DS, Sia RK, Kitt JP, Harris JM, Hsu KL, Libby A, Odrich MG, Suárez T, McKown RL, Laurie GW. Georgiev GA, et al. Among authors: mckown rl. J Biol Chem. 2021 Jan-Jun;296:100070. doi: 10.1074/jbc.RA120.015833. Epub 2020 Nov 21. J Biol Chem. 2021. PMID: 33187980 Free PMC article.
61 results