Helleday T - Search Results

1

MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG.

Rudd SG, Gad H, Sanjiv K, Amaral N, Hagenkort A, Groth P, Ström CE, Mortusewicz O, Berglund UW, Helleday T. Rudd SG, et al. Among authors: helleday t. Cancer Res. 2020 Sep 1;80(17):3530-3541. doi: 10.1158/0008-5472.CAN-19-0883. Epub 2020 Apr 20. Cancer Res. 2020. PMID: 32312836 Free article.

2

XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair.

Parsons JL, Dianova II, Finch D, Tait PS, Ström CE, Helleday T, Dianov GL. Parsons JL, et al. Among authors: helleday t. DNA Repair (Amst). 2010 Jul 1;9(7):835-41. doi: 10.1016/j.dnarep.2010.04.008. Epub 2010 May 14. DNA Repair (Amst). 2010. PMID: 20471329

3

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.

Gottipati P, Vischioni B, Schultz N, Solomons J, Bryant HE, Djureinovic T, Issaeva N, Sleeth K, Sharma RA, Helleday T. Gottipati P, et al. Among authors: helleday t. Cancer Res. 2010 Jul 1;70(13):5389-98. doi: 10.1158/0008-5472.CAN-09-4716. Epub 2010 Jun 15. Cancer Res. 2010. PMID: 20551068 Free article.

4

6-thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance.

Issaeva N, Thomas HD, Djureinovic T, Jaspers JE, Stoimenov I, Kyle S, Pedley N, Gottipati P, Zur R, Sleeth K, Chatzakos V, Mulligan EA, Lundin C, Gubanova E, Kersbergen A, Harris AL, Sharma RA, Rottenberg S, Curtin NJ, Helleday T. Issaeva N, et al. Among authors: helleday t. Cancer Res. 2010 Aug 1;70(15):6268-76. doi: 10.1158/0008-5472.CAN-09-3416. Epub 2010 Jul 14. Cancer Res. 2010. PMID: 20631063 Free PMC article.

5

Methylated DNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or DNA single-strand breaks and results in DNA damage.

Groth P, Ausländer S, Majumder MM, Schultz N, Johansson F, Petermann E, Helleday T. Groth P, et al. Among authors: helleday t. J Mol Biol. 2010 Sep 10;402(1):70-82. doi: 10.1016/j.jmb.2010.07.010. Epub 2010 Jul 17. J Mol Biol. 2010. PMID: 20643142

6

Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate.

Ström CE, Johansson F, Uhlén M, Szigyarto CA, Erixon K, Helleday T. Ström CE, et al. Among authors: helleday t. Nucleic Acids Res. 2011 Apr;39(8):3166-75. doi: 10.1093/nar/gkq1241. Epub 2010 Dec 22. Nucleic Acids Res. 2011. PMID: 21183466 Free PMC article.

7

ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.

Segal-Raz H, Mass G, Baranes-Bachar K, Lerenthal Y, Wang SY, Chung YM, Ziv-Lehrman S, Ström CE, Helleday T, Hu MC, Chen DJ, Shiloh Y. Segal-Raz H, et al. Among authors: helleday t. EMBO Rep. 2011 Jul 1;12(7):713-9. doi: 10.1038/embor.2011.96. EMBO Rep. 2011. PMID: 21637298 Free PMC article.

8

UV stalled replication forks restart by re-priming in human fibroblasts.

Elvers I, Johansson F, Groth P, Erixon K, Helleday T. Elvers I, et al. Among authors: helleday t. Nucleic Acids Res. 2011 Sep 1;39(16):7049-57. doi: 10.1093/nar/gkr420. Epub 2011 Jun 6. Nucleic Acids Res. 2011. PMID: 21646340 Free PMC article.

9

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex.

Svensson LM, Jemth AS, Desroses M, Loseva O, Helleday T, Högbom M, Stenmark P. Svensson LM, et al. Among authors: helleday t. FEBS Lett. 2011 Aug 19;585(16):2617-21. doi: 10.1016/j.febslet.2011.07.017. Epub 2011 Jul 23. FEBS Lett. 2011. PMID: 21787772 Free article.

10

CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair.

Ström CE, Mortusewicz O, Finch D, Parsons JL, Lagerqvist A, Johansson F, Schultz N, Erixon K, Dianov GL, Helleday T. Ström CE, et al. Among authors: helleday t. DNA Repair (Amst). 2011 Sep 5;10(9):961-9. doi: 10.1016/j.dnarep.2011.07.004. Epub 2011 Aug 15. DNA Repair (Amst). 2011. PMID: 21840775

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