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5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1.
Green AR, Freedman C, Tena J, Tourdot BE, Liu B, Holinstat M, Holman TR. Green AR, et al. Among authors: tourdot be. Biochemistry. 2018 Dec 4;57(48):6726-6734. doi: 10.1021/acs.biochem.8b00889. Epub 2018 Nov 15. Biochemistry. 2018. PMID: 30407793 Free PMC article.
Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1.
Perry SC, Horn T, Tourdot BE, Yamaguchi A, Kalyanaraman C, Conrad WS, Akinkugbe O, Holinstat M, Jacobson MP, Holman TR. Perry SC, et al. Among authors: tourdot be. Biochemistry. 2020 Oct 27;59(42):4118-4130. doi: 10.1021/acs.biochem.0c00622. Epub 2020 Oct 13. Biochemistry. 2020. PMID: 33048542 Free PMC article.
Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation.
Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M. Yeung J, et al. Among authors: tourdot be. Blood. 2014 Oct 2;124(14):2271-9. doi: 10.1182/blood-2014-05-575878. Epub 2014 Aug 6. Blood. 2014. PMID: 25100742 Free PMC article.
First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis.
Adili R, Tourdot BE, Mast K, Yeung J, Freedman JC, Green A, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, Holinstat M. Adili R, et al. Among authors: tourdot be. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1828-1839. doi: 10.1161/ATVBAHA.117.309868. Epub 2017 Aug 3. Arterioscler Thromb Vasc Biol. 2017. PMID: 28775075 Free PMC article.
23 results