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Page 1
Recent approaches to gout drug discovery: an update.
Otani N, Ouchi M, Kudo H, Tsuruoka S, Hisatome I, Anzai N. Otani N, et al. Among authors: hisatome i. Expert Opin Drug Discov. 2020 Aug;15(8):943-954. doi: 10.1080/17460441.2020.1755251. Epub 2020 Apr 24. Expert Opin Drug Discov. 2020. PMID: 32329387 Review.
Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial.
Ogihara T, Saruta T, Rakugi H, Saito I, Shimamoto K, Matsuoka H, Shimada K, Ito S, Horiuchi M, Imaizumi T, Takishita S, Higaki J, Katayama S, Kimura G, Umemura S, Ura N, Hayashi K, Odawara M, Tanahashi N, Ishimitsu T, Kashihara N, Morita S, Teramukai S; COLM Investigators. Ogihara T, et al. J Hypertens. 2014 Oct;32(10):2054-63; discussiom 2063. doi: 10.1097/HJH.0000000000000281. J Hypertens. 2014. PMID: 24999799 Free PMC article. Clinical Trial.
Effects of Uric Acid on the NO Production of HUVECs and its Restoration by Urate Lowering Agents.
Mishima M, Hamada T, Maharani N, Ikeda N, Onohara T, Notsu T, Ninomiya H, Miyazaki S, Mizuta E, Sugihara S, Kato M, Ogino K, Kuwabara M, Hirota Y, Yoshida A, Otani N, Anzai N, Hisatome I. Mishima M, et al. Among authors: hisatome i. Drug Res (Stuttg). 2016 May;66(5):270-4. doi: 10.1055/s-0035-1569405. Epub 2016 Feb 24. Drug Res (Stuttg). 2016. PMID: 26909689
Molecular mechanisms underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells.
Onohara T, Hisatome I, Kurata Y, Li P, Notsu T, Morikawa K, Otani N, Yoshida A, Iitsuka K, Kato M, Miake J, Ninomiya H, Higaki K, Shirayoshi Y, Nishihara T, Itoh T, Nakamura Y, Nishimura M. Onohara T, et al. Among authors: hisatome i. J Arrhythm. 2017 Jun;33(3):226-233. doi: 10.1016/j.joa.2016.09.003. Epub 2016 Oct 19. J Arrhythm. 2017. PMID: 28607619 Free PMC article.
Protective Effects of Topiroxostat on an Ischemia-Reperfusion Model of Rat Hearts.
Tanno S, Yamamoto K, Kurata Y, Adachi M, Inoue Y, Otani N, Mishima M, Yamamoto Y, Kuwabara M, Ogino K, Miake J, Ninomiya H, Shirayoshi Y, Okada F, Yamamoto K, Hisatome I. Tanno S, et al. Among authors: hisatome i. Circ J. 2018 Mar 23;82(4):1101-1111. doi: 10.1253/circj.CJ-17-1049. Epub 2018 Feb 28. Circ J. 2018. PMID: 29491325 Free article.
Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes.
Taufiq F, Maharani N, Li P, Kurata Y, Ikeda N, Kuwabara M, Otani N, Miake J, Hasegawa A, Tsuneto M, Shirayoshi Y, Ninomiya H, Saitoh T, Nakai A, Yamamoto K, Hisatome I. Taufiq F, et al. Among authors: hisatome i. Circ J. 2019 Mar 25;83(4):718-726. doi: 10.1253/circj.CJ-18-1088. Epub 2019 Feb 20. Circ J. 2019. PMID: 30787218 Free article.
Evidence for Urate Uptake Through Monocarboxylate Transporter 9 Expressed in Mammalian Cells and Its Enhancement by Heat Shock.
Otani N, Kurata Y, Maharani N, Kuwabara M, Ikeda N, Notsu T, Li P, Miake J, Yoshida A, Sakaguchi H, Higaki K, Nakasone N, Tsuneto M, Shirayoshi Y, Ouchi M, Ninomiya H, Yamamoto K, Anzai N, Hisatome I. Otani N, et al. Among authors: hisatome i. Circ Rep. 2020 Jul 2;2(8):425-432. doi: 10.1253/circrep.CR-20-0016. Circ Rep. 2020. PMID: 33693264 Free PMC article.
Hypouricemia and Urate Transporters.
Otani N, Ouchi M, Misawa K, Hisatome I, Anzai N. Otani N, et al. Among authors: hisatome i. Biomedicines. 2022 Mar 11;10(3):652. doi: 10.3390/biomedicines10030652. Biomedicines. 2022. PMID: 35327453 Free PMC article. Review.
374 results