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Engineering the Live-Attenuated Polio Vaccine to Prevent Reversion to Virulence.
Yeh MT, Bujaki E, Dolan PT, Smith M, Wahid R, Konz J, Weiner AJ, Bandyopadhyay AS, Van Damme P, De Coster I, Revets H, Macadam A, Andino R. Yeh MT, et al. Among authors: macadam a. Cell Host Microbe. 2020 May 13;27(5):736-751.e8. doi: 10.1016/j.chom.2020.04.003. Epub 2020 Apr 23. Cell Host Microbe. 2020. PMID: 32330425 Free PMC article. Clinical Trial.
The Evolutionary Pathway to Virulence of an RNA Virus.
Stern A, Yeh MT, Zinger T, Smith M, Wright C, Ling G, Nielsen R, Macadam A, Andino R. Stern A, et al. Among authors: macadam a. Cell. 2017 Mar 23;169(1):35-46.e19. doi: 10.1016/j.cell.2017.03.013. Cell. 2017. PMID: 28340348 Free PMC article.
Pathogenic Events in a Nonhuman Primate Model of Oral Poliovirus Infection Leading to Paralytic Poliomyelitis.
Shen L, Chen CY, Huang D, Wang R, Zhang M, Qian L, Zhu Y, Zhang AZ, Yang E, Qaqish A, Chumakov K, Kouiavskaia D, Vignuzzi M, Nathanson N, Macadam AJ, Andino R, Kew O, Xu J, Chen ZW. Shen L, et al. Among authors: macadam aj. J Virol. 2017 Jun 26;91(14):e02310-16. doi: 10.1128/JVI.02310-16. Print 2017 Jul 15. J Virol. 2017. PMID: 28356537 Free PMC article.
The safety and immunogenicity of two novel live attenuated monovalent (serotype 2) oral poliovirus vaccines in healthy adults: a double-blind, single-centre phase 1 study.
Van Damme P, De Coster I, Bandyopadhyay AS, Revets H, Withanage K, De Smedt P, Suykens L, Oberste MS, Weldon WC, Costa-Clemens SA, Clemens R, Modlin J, Weiner AJ, Macadam AJ, Andino R, Kew OM, Konopka-Anstadt JL, Burns CC, Konz J, Wahid R, Gast C. Van Damme P, et al. Lancet. 2019 Jul 13;394(10193):148-158. doi: 10.1016/S0140-6736(19)31279-6. Epub 2019 Jun 4. Lancet. 2019. PMID: 31174831 Free PMC article. Clinical Trial.
Development of a new oral poliovirus vaccine for the eradication end game using codon deoptimization.
Konopka-Anstadt JL, Campagnoli R, Vincent A, Shaw J, Wei L, Wynn NT, Smithee SE, Bujaki E, Te Yeh M, Laassri M, Zagorodnyaya T, Weiner AJ, Chumakov K, Andino R, Macadam A, Kew O, Burns CC. Konopka-Anstadt JL, et al. Among authors: macadam a. NPJ Vaccines. 2020 Mar 20;5(1):26. doi: 10.1038/s41541-020-0176-7. eCollection 2020. NPJ Vaccines. 2020. PMID: 32218998 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33580064
Evaluation and validation of next-generation sequencing to support lot release for a novel type 2 oral poliovirus vaccine.
Konz JO, Schofield T, Carlyle S, Wahid R, Ansari A, Strating JRPM, Yeh MT, Manukyan H, Smits SL, Tritama E, Rahmah L, Ugiyadi D, Andino R, Laassri M, Chumakov K, Macadam A. Konz JO, et al. Among authors: macadam a. Vaccine X. 2021 Jun 11;8:100102. doi: 10.1016/j.jvacx.2021.100102. eCollection 2021 Aug. Vaccine X. 2021. PMID: 34195600 Free PMC article.
Assessment of genetic changes and neurovirulence of shed Sabin and novel type 2 oral polio vaccine viruses.
Wahid R, Mercer L, Macadam A, Carlyle S, Stephens L, Martin J, Chumakov K, Laassri M, Petrovskaya S, Smits SL, Stittelaar KJ, Gast C, Weldon WC, Konopka-Anstadt JL, Steven Oberste M, Van Damme P, De Coster I, Rüttimann R, Bandyopadhyay A, Konz J. Wahid R, et al. Among authors: macadam a. NPJ Vaccines. 2021 Jul 29;6(1):94. doi: 10.1038/s41541-021-00355-y. NPJ Vaccines. 2021. PMID: 34326330 Free PMC article.
Evaluating stability of attenuated Sabin and two novel type 2 oral poliovirus vaccines in children.
Wahid R, Mercer L, Gast C, De Leon T, Sáez-Llorens X, Fix A, Macadam A, Stephens L, Chumakov K, Smits SL, Murreddu M, Konopka-Anstadt JL, Steven Oberste M, Burns CC, Andino R, Bachtiar NS, Tritama E, Bandyopadhyay AS, Aguirre G, Rüttimann R, Konz JO. Wahid R, et al. Among authors: macadam a. NPJ Vaccines. 2022 Feb 11;7(1):19. doi: 10.1038/s41541-022-00437-5. NPJ Vaccines. 2022. PMID: 35149714 Free PMC article.
Genetic Characterization of Novel Oral Polio Vaccine Type 2 Viruses During Initial Use Phase Under Emergency Use Listing - Worldwide, March-October 2021.
Martin J, Burns CC, Jorba J, Shulman LM, Macadam A, Klapsa D, Majumdar M, Bullows J, Frolov A, Mate R, Bujaki E, Castro CJ, Bullard K, Konz J, Hawes K, Gauld J, Blake IM, Mercer LD, Kurji F, Voorman A, Diop OM, Oberste MS, Modlin J, Macklin G, Eisenhawer M, Bandyopadhyay AS, Zipursky S. Martin J, et al. Among authors: macadam a. MMWR Morb Mortal Wkly Rep. 2022 Jun 17;71(24):786-790. doi: 10.15585/mmwr.mm7124a2. MMWR Morb Mortal Wkly Rep. 2022. PMID: 35709073 Free article.
63 results