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SPINT2 (HAI-2) missense variants identified in congenital sodium diarrhea/tufting enteropathy affect the ability of HAI-2 to inhibit prostasin but not matriptase.
Holt-Danborg L, Vodopiutz J, Nonboe AW, De Laffolie J, Skovbjerg S, Wolters VM, Müller T, Hetzer B, Querfurt A, Zimmer KP, Jensen JK, Entenmann A, Heinz-Erian P, Vogel LK, Janecke AR. Holt-Danborg L, et al. Among authors: jensen jk. Hum Mol Genet. 2019 Mar 1;28(5):828-841. doi: 10.1093/hmg/ddy394. Hum Mol Genet. 2019. PMID: 30445423
Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase.
Larsen BR, Steffensen SD, Nielsen NV, Friis S, Godiksen S, Bornholdt J, Soendergaard C, Nonboe AW, Andersen MN, Poulsen SS, Szabo R, Bugge TH, Lin CY, Skovbjerg H, Jensen JK, Vogel LK. Larsen BR, et al. Among authors: jensen jk. Exp Cell Res. 2013 Apr 1;319(6):918-29. doi: 10.1016/j.yexcr.2013.01.008. Epub 2013 Jan 16. Exp Cell Res. 2013. PMID: 23333561 Free PMC article.
Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN.
Hong Z, De Meulemeester L, Jacobi A, Pedersen JS, Morth JP, Andreasen PA, Jensen JK. Hong Z, et al. Among authors: jensen jk. J Biol Chem. 2016 Jul 1;291(27):14340-14355. doi: 10.1074/jbc.M115.707240. Epub 2016 May 6. J Biol Chem. 2016. PMID: 27189939 Free PMC article.
261 results