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Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.
Psaila B, Wang G, Rodriguez-Meira A, Li R, Heuston EF, Murphy L, Yee D, Hitchcock IS, Sousos N, O'Sullivan J, Anderson S, Senis YA, Weinberg OK, Calicchio ML; NIH Intramural Sequencing Center; Iskander D, Royston D, Milojkovic D, Roberts I, Bodine DM, Thongjuea S, Mead AJ. Psaila B, et al. Among authors: hitchcock is. Mol Cell. 2020 May 7;78(3):477-492.e8. doi: 10.1016/j.molcel.2020.04.008. Mol Cell. 2020. PMID: 32386542 Free PMC article.
Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.
Tsutsumi N, Masoumi Z, James SC, Tucker JA, Winkelmann H, Grey W, Picton LK, Moss L, Wilson SC, Caveney NA, Jude KM, Gati C, Piehler J, Hitchcock IS, Garcia KC. Tsutsumi N, et al. Among authors: hitchcock is. Cell. 2023 Sep 14;186(19):4189-4203.e22. doi: 10.1016/j.cell.2023.07.037. Epub 2023 Aug 25. Cell. 2023. PMID: 37633268 Free article.
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.
Cui L, Moraga I, Lerbs T, Van Neste C, Wilmes S, Tsutsumi N, Trotman-Grant AC, Gakovic M, Andrews S, Gotlib J, Darmanis S, Enge M, Quake S, Hitchcock IS, Piehler J, Garcia KC, Wernig G. Cui L, et al. Among authors: hitchcock is. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2017849118. doi: 10.1073/pnas.2017849118. Proc Natl Acad Sci U S A. 2021. PMID: 33384332 Free PMC article.
Novel ET mutations: stuck in the MPL with you.
Hitchcock IS. Hitchcock IS. Blood. 2020 Mar 19;135(12):889-890. doi: 10.1182/blood.2020005000. Blood. 2020. PMID: 32191801 Free article. No abstract available.
31 results