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Single-Cell Analyses Reveal Megakaryocyte-Biased Hematopoiesis in Myelofibrosis and Identify Mutant Clone-Specific Targets.
Psaila B, Wang G, Rodriguez-Meira A, Li R, Heuston EF, Murphy L, Yee D, Hitchcock IS, Sousos N, O'Sullivan J, Anderson S, Senis YA, Weinberg OK, Calicchio ML; NIH Intramural Sequencing Center; Iskander D, Royston D, Milojkovic D, Roberts I, Bodine DM, Thongjuea S, Mead AJ. Psaila B, et al. Among authors: senis ya. Mol Cell. 2020 May 7;78(3):477-492.e8. doi: 10.1016/j.molcel.2020.04.008. Mol Cell. 2020. PMID: 32386542 Free PMC article.
Congenital macrothrombocytopenia with focal myelofibrosis due to mutations in human G6b-B is rescued in humanized mice.
Hofmann I, Geer MJ, Vögtle T, Crispin A, Campagna DR, Barr A, Calicchio ML, Heising S, van Geffen JP, Kuijpers MJE, Heemskerk JWM, Eble JA, Schmitz-Abe K, Obeng EA, Douglas M, Freson K, Pondarré C, Favier R, Jarvis GE, Markianos K, Turro E, Ouwehand WH, Mazharian A, Fleming MD, Senis YA. Hofmann I, et al. Among authors: senis ya. Blood. 2018 Sep 27;132(13):1399-1412. doi: 10.1182/blood-2017-08-802769. Epub 2018 Jun 13. Blood. 2018. PMID: 29898956 Free PMC article.
Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B.
Vögtle T, Sharma S, Mori J, Nagy Z, Semeniak D, Scandola C, Geer MJ, Smith CW, Lane J, Pollack S, Lassila R, Jouppila A, Barr AJ, Ogg DJ, Howard TD, McMiken HJ, Warwicker J, Geh C, Rowlinson R, Abbott WM, Eckly A, Schulze H, Wright GJ, Mazharian A, Fütterer K, Rajesh S, Douglas MR, Senis YA. Vögtle T, et al. Among authors: senis ya. Elife. 2019 Aug 22;8:e46840. doi: 10.7554/eLife.46840. Elife. 2019. PMID: 31436532 Free PMC article.
A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein.
Senis YA, Tomlinson MG, García A, Dumon S, Heath VL, Herbert J, Cobbold SP, Spalton JC, Ayman S, Antrobus R, Zitzmann N, Bicknell R, Frampton J, Authi KS, Martin A, Wakelam MJ, Watson SP. Senis YA, et al. Mol Cell Proteomics. 2007 Mar;6(3):548-64. doi: 10.1074/mcp.D600007-MCP200. Epub 2006 Dec 23. Mol Cell Proteomics. 2007. PMID: 17186946 Free PMC article.
Proplatelets slip slidin' away.
Mazharian A, Senis YA. Mazharian A, et al. Among authors: senis ya. Blood. 2015 Jan 29;125(5):747-8. doi: 10.1182/blood-2014-12-614131. Blood. 2015. PMID: 25634614 Free article.
Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.
Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A, Weiss A, Mazharian A, Senis YA. Mori J, et al. Among authors: senis ya. Blood. 2018 Mar 8;131(10):1122-1144. doi: 10.1182/blood-2017-02-768077. Epub 2018 Jan 4. Blood. 2018. PMID: 29301754 Free PMC article.
Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.
Geer MJ, van Geffen JP, Gopalasingam P, Vögtle T, Smith CW, Heising S, Kuijpers MJE, Tullemans BME, Jarvis GE, Eble JA, Jeeves M, Overduin M, Heemskerk JWM, Mazharian A, Senis YA. Geer MJ, et al. Among authors: senis ya. Blood. 2018 Sep 27;132(13):1413-1425. doi: 10.1182/blood-2017-10-802975. Epub 2018 Jun 11. Blood. 2018. PMID: 29891536 Free PMC article.
70 results