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Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes.
Yeo L, Woodwyk A, Sood S, Lorenc A, Eichmann M, Pujol-Autonell I, Melchiotti R, Skowera A, Fidanis E, Dolton GM, Tungatt K, Sewell AK, Heck S, Saxena A, Beam CA, Peakman M. Yeo L, et al. Among authors: peakman m. J Clin Invest. 2018 Aug 1;128(8):3460-3474. doi: 10.1172/JCI120555. Epub 2018 Jul 16. J Clin Invest. 2018. PMID: 29851415 Free PMC article. Clinical Trial.
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes.
Edner NM, Heuts F, Thomas N, Wang CJ, Petersone L, Kenefeck R, Kogimtzis A, Ovcinnikovs V, Ross EM, Ntavli E, Elfaki Y, Eichmann M, Baptista R, Ambery P, Jermutus L, Peakman M, Rosenthal M, Walker LSK. Edner NM, et al. Among authors: peakman m. Nat Immunol. 2020 Oct;21(10):1244-1255. doi: 10.1038/s41590-020-0744-z. Epub 2020 Aug 3. Nat Immunol. 2020. PMID: 32747817 Free PMC article. Clinical Trial.
Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells.
Kronenberg D, Knight RR, Estorninho M, Ellis RJ, Kester MG, de Ru A, Eichmann M, Huang GC, Powrie J, Dayan CM, Skowera A, van Veelen PA, Peakman M. Kronenberg D, et al. Among authors: peakman m. Diabetes. 2012 Jul;61(7):1752-9. doi: 10.2337/db11-1520. Epub 2012 Apr 20. Diabetes. 2012. PMID: 22522618 Free PMC article.
Reduction in CD4 central memory T-cell subset in costimulation modulator abatacept-treated patients with recent-onset type 1 diabetes is associated with slower C-peptide decline.
Orban T, Beam CA, Xu P, Moore K, Jiang Q, Deng J, Muller S, Gottlieb P, Spain L, Peakman M; Type 1 Diabetes TrialNet Abatacept Study Group. Orban T, et al. Among authors: peakman m. Diabetes. 2014 Oct;63(10):3449-57. doi: 10.2337/db14-0047. Epub 2014 May 16. Diabetes. 2014. PMID: 24834977 Free PMC article. Clinical Trial.
β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure.
Skowera A, Ladell K, McLaren JE, Dolton G, Matthews KK, Gostick E, Kronenberg-Versteeg D, Eichmann M, Knight RR, Heck S, Powrie J, Bingley PJ, Dayan CM, Miles JJ, Sewell AK, Price DA, Peakman M. Skowera A, et al. Among authors: peakman m. Diabetes. 2015 Mar;64(3):916-925. doi: 10.2337/db14-0332. Epub 2014 Sep 23. Diabetes. 2015. PMID: 25249579 Free PMC article.
290 results