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Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity.
Emrich SM, Yoast RE, Xin P, Zhang X, Pathak T, Nwokonko R, Gueguinou MF, Subedi KP, Zhou Y, Ambudkar IS, Hempel N, Machaca K, Gill DL, Trebak M. Emrich SM, et al. Among authors: xin p. J Biol Chem. 2019 Apr 19;294(16):6318-6332. doi: 10.1074/jbc.RA118.006801. Epub 2019 Mar 1. J Biol Chem. 2019. PMID: 30824535 Free PMC article.
L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins.
Johnson MT, Gudlur A, Zhang X, Xin P, Emrich SM, Yoast RE, Courjaret R, Nwokonko RM, Li W, Hempel N, Machaca K, Gill DL, Hogan PG, Trebak M. Johnson MT, et al. Among authors: xin p. Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17369-17380. doi: 10.1073/pnas.2007598117. Epub 2020 Jul 8. Proc Natl Acad Sci U S A. 2020. PMID: 32641503 Free PMC article.
Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels.
Zhang X, Xin P, Yoast RE, Emrich SM, Johnson MT, Pathak T, Benson JC, Azimi I, Gill DL, Monteith GR, Trebak M. Zhang X, et al. Among authors: xin p. Cell Calcium. 2020 Nov;91:102281. doi: 10.1016/j.ceca.2020.102281. Epub 2020 Aug 29. Cell Calcium. 2020. PMID: 32896813 Free PMC article.
The Orai1 Store-operated Calcium Channel Functions as a Hexamer.
Cai X, Zhou Y, Nwokonko RM, Loktionova NA, Wang X, Xin P, Trebak M, Wang Y, Gill DL. Cai X, et al. Among authors: xin p. J Biol Chem. 2016 Dec 9;291(50):25764-25775. doi: 10.1074/jbc.M116.758813. Epub 2016 Oct 25. J Biol Chem. 2016. PMID: 27780862 Free PMC article.
Cross-linking of Orai1 channels by STIM proteins.
Zhou Y, Nwokonko RM, Cai X, Loktionova NA, Abdulqadir R, Xin P, Niemeyer BA, Wang Y, Trebak M, Gill DL. Zhou Y, et al. Among authors: xin p. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3398-E3407. doi: 10.1073/pnas.1720810115. Epub 2018 Mar 26. Proc Natl Acad Sci U S A. 2018. PMID: 29581306 Free PMC article.
A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions.
Azimi I, Stevenson RJ, Zhang X, Meizoso-Huesca A, Xin P, Johnson M, Flanagan JU, Chalmers SB, Yoast RE, Kapure JS, Ross BP, Vetter I, Ashton MR, Launikonis BS, Denny WA, Trebak M, Monteith GR. Azimi I, et al. Among authors: xin p. ACS Pharmacol Transl Sci. 2020 Feb 14;3(1):135-147. doi: 10.1021/acsptsci.9b00081. Epub 2020 Jan 13. ACS Pharmacol Transl Sci. 2020. PMID: 32190822 Free PMC article.
315 results