Kirwan P - Search Results

1

Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities.

Sonoyama T, Stadler LKJ, Zhu M, Keogh JM, Henning E, Hisama F, Kirwan P, Jura M, Blaszczyk BK, DeWitt DC, Brouwers B, Hyvönen M, Barroso I, Merkle FT, Appleyard SM, Wayman GA, Farooqi IS. Sonoyama T, et al. Among authors: kirwan p. Sci Rep. 2020 Jun 3;10(1):9028. doi: 10.1038/s41598-020-65531-x. Sci Rep. 2020. PMID: 32493978 Free PMC article.

2

Generation and Characterization of Functional Human Hypothalamic Neurons.

Kirwan P, Jura M, Merkle FT. Kirwan P, et al. Curr Protoc Neurosci. 2017 Oct 24;81:3.33.1-3.33.24. doi: 10.1002/cpns.40. Curr Protoc Neurosci. 2017. PMID: 29064566

3

Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights.

Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C. Heeley N, et al. Among authors: kirwan p. Mol Metab. 2018 Apr;10:14-27. doi: 10.1016/j.molmet.2018.01.021. Epub 2018 Feb 7. Mol Metab. 2018. PMID: 29439854 Free PMC article.

4

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.

Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O'Rahilly S, Merkle FT. Kirwan P, et al. Mol Metab. 2018 Nov;17:82-97. doi: 10.1016/j.molmet.2018.08.006. Epub 2018 Aug 21. Mol Metab. 2018. PMID: 30201275 Free PMC article.

5

Proopiomelanocortin Processing in the Hypothalamus Is Directly Regulated by Saturated Fat: Implications for the Development of Obesity.

Razolli DS, de Araújo TM, Sant Apos Ana MR, Kirwan P, Cintra DE, Merkle FT, Velloso LA. Razolli DS, et al. Among authors: kirwan p. Neuroendocrinology. 2020;110(1-2):92-104. doi: 10.1159/000501023. Epub 2019 May 20. Neuroendocrinology. 2020. PMID: 31104058 Free PMC article.

6

APP metabolism regulates tau proteostasis in human cerebral cortex neurons.

Moore S, Evans LD, Andersson T, Portelius E, Smith J, Dias TB, Saurat N, McGlade A, Kirwan P, Blennow K, Hardy J, Zetterberg H, Livesey FJ. Moore S, et al. Among authors: kirwan p. Cell Rep. 2015 May 5;11(5):689-96. doi: 10.1016/j.celrep.2015.03.068. Epub 2015 Apr 23. Cell Rep. 2015. PMID: 25921538 Free PMC article.

7

The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro.

Ali FR, Cheng K, Kirwan P, Metcalfe S, Livesey FJ, Barker RA, Philpott A. Ali FR, et al. Among authors: kirwan p. Development. 2014 Jun;141(11):2216-24. doi: 10.1242/dev.106377. Epub 2014 May 12. Development. 2014. PMID: 24821983

8

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.

Shi Y, Kirwan P, Smith J, Robinson HP, Livesey FJ. Shi Y, et al. Among authors: kirwan p. Nat Neurosci. 2012 Feb 5;15(3):477-86, S1. doi: 10.1038/nn.3041. Nat Neurosci. 2012. PMID: 22306606 Free PMC article.

9

Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.

Kirwan P, Turner-Bridger B, Peter M, Momoh A, Arambepola D, Robinson HP, Livesey FJ. Kirwan P, et al. Development. 2015 Sep 15;142(18):3178-87. doi: 10.1242/dev.123851. Development. 2015. PMID: 26395144 Free PMC article.

10

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks.

Shi Y, Kirwan P, Livesey FJ. Shi Y, et al. Among authors: kirwan p. Nat Protoc. 2012 Oct;7(10):1836-46. doi: 10.1038/nprot.2012.116. Epub 2012 Sep 13. Nat Protoc. 2012. PMID: 22976355

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