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POLE Mutation Spectra Are Shaped by the Mutant Allele Identity, Its Abundance, and Mismatch Repair Status.
Mol Cell. 2020 Jun 18;78(6):1166-1177.e6. doi: 10.1016/j.molcel.2020.05.012. Epub 2020 Jun 3.
Mol Cell. 2020.
PMID: 32497495
Free PMC article.
POLE proofreading defects: Contributions to mutagenesis and cancer.
Park VS, Pursell ZF.
Park VS, et al.
DNA Repair (Amst). 2019 Apr;76:50-59. doi: 10.1016/j.dnarep.2019.02.007. Epub 2019 Feb 16.
DNA Repair (Amst). 2019.
PMID: 30818169
Free PMC article.
Review.
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Cancers from Novel Pole-Mutant Mouse Models Provide Insights into Polymerase-Mediated Hypermutagenesis and Immune Checkpoint Blockade.
Galati MA, Hodel KP, Gams MS, Sudhaman S, Bridge T, Zahurancik WJ, Ungerleider NA, Park VS, Ercan AB, Joksimovic L, Siddiqui I, Siddaway R, Edwards M, de Borja R, Elshaer D, Chung J, Forster VJ, Nunes NM, Aronson M, Wang X, Ramdas J, Seeley A, Sarosiek T, Dunn GP, Byrd JN, Mordechai O, Durno C, Martin A, Shlien A, Bouffet E, Suo Z, Jackson JG, Hawkins CE, Guidos CJ, Pursell ZF, Tabori U.
Galati MA, et al. Among authors: park vs.
Cancer Res. 2020 Dec 15;80(24):5606-5618. doi: 10.1158/0008-5472.CAN-20-0624. Epub 2020 Sep 16.
Cancer Res. 2020.
PMID: 32938641
Free PMC article.
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Mouse model and human patient data reveal critical roles for Pten and p53 in suppressing POLE mutant tumor development.
Park VS, Sun MJS, Frey WD, Williams LG, Hodel KP, Strauss JD, Wellens SJ, Jackson JG, Pursell ZF.
Park VS, et al.
NAR Cancer. 2022 Mar 3;4(1):zcac004. doi: 10.1093/narcan/zcac004. eCollection 2022 Mar.
NAR Cancer. 2022.
PMID: 35252866
Free PMC article.
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Light-strand bias and enriched zones of embedded ribonucleotides are associated with DNA replication and transcription in the human-mitochondrial genome.
Xu P, Yang T, Kundnani DL, Sun M, Marsili S, Gombolay AL, Jeon Y, Newnam G, Balachander S, Bazzani V, Baccarani U, Park VS, Tao S, Lori A, Schinazi RF, Kim B, Pursell ZF, Tell G, Vascotto C, Storici F.
Xu P, et al. Among authors: park vs.
Nucleic Acids Res. 2024 Feb 9;52(3):1207-1225. doi: 10.1093/nar/gkad1204.
Nucleic Acids Res. 2024.
PMID: 38117983
Free PMC article.
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