Phillips JJ - Search Results

1

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity.

Stephens AD, Zacharopoulou M, Moons R, Fusco G, Seetaloo N, Chiki A, Woodhams PJ, Mela I, Lashuel HA, Phillips JJ, De Simone A, Sobott F, Schierle GSK. Stephens AD, et al. Among authors: phillips jj. Nat Commun. 2020 Jun 4;11(1):2820. doi: 10.1038/s41467-020-16564-3. Nat Commun. 2020. PMID: 32499486 Free PMC article.

2

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase.

Klein T, Vajpai N, Phillips JJ, Davies G, Holdgate GA, Phillips C, Tucker JA, Norman RA, Scott AD, Higazi DR, Lowe D, Thompson GS, Breeze AL. Klein T, et al. Among authors: phillips jj, phillips c. Nat Commun. 2015 Jul 23;6:7877. doi: 10.1038/ncomms8877. Nat Commun. 2015. PMID: 26203596 Free PMC article.

3

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction.

Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M, Pinotsi D, Zago W, Fraser P, Tandon A, St George-Hyslop P, Rees E, Phillips JJ, De Simone A, Kaminski CF, Schierle GSK. Lautenschläger J, et al. Among authors: phillips jj. Nat Commun. 2018 Feb 19;9(1):712. doi: 10.1038/s41467-018-03111-4. Nat Commun. 2018. PMID: 29459792 Free PMC article.

4

Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing.

Stephens AD, Nespovitaya N, Zacharopoulou M, Kaminski CF, Phillips JJ, Kaminski Schierle GS. Stephens AD, et al. Among authors: phillips jj. Anal Chem. 2018 Jun 5;90(11):6975-6983. doi: 10.1021/acs.analchem.8b01264. Epub 2018 May 22. Anal Chem. 2018. PMID: 29750859 Free PMC article.

5

HDfleX: Software for Flexible High Structural Resolution of Hydrogen/Deuterium-Exchange Mass Spectrometry Data.

Seetaloo N, Kish M, Phillips JJ. Seetaloo N, et al. Among authors: phillips jj. Anal Chem. 2022 Mar 22;94(11):4557-4564. doi: 10.1021/acs.analchem.1c05339. Epub 2022 Mar 9. Anal Chem. 2022. PMID: 35263087 Free PMC article.

6

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions.

Seetaloo N, Phillips JJ. Seetaloo N, et al. Among authors: phillips jj. J Vis Exp. 2022 Jun 23;(184). doi: 10.3791/64050. J Vis Exp. 2022. PMID: 35815971

7

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry Approach to Correlate Local Structure and Aggregation in α-Synuclein.

Seetaloo N, Zacharopoulou M, Stephens AD, Kaminski Schierle GS, Phillips JJ. Seetaloo N, et al. Among authors: phillips jj. Anal Chem. 2022 Dec 6;94(48):16711-16719. doi: 10.1021/acs.analchem.2c03183. Epub 2022 Nov 22. Anal Chem. 2022. PMID: 36413494 Free PMC article.

8

Engineering and exploiting synthetic allostery of NanoLuc luciferase.

Guo Z, Parakra RD, Xiong Y, Johnston WA, Walden P, Edwardraja S, Moradi SV, Ungerer JPJ, Ai HW, Phillips JJ, Alexandrov K. Guo Z, et al. Among authors: phillips jj. Nat Commun. 2022 Feb 10;13(1):789. doi: 10.1038/s41467-022-28425-2. Nat Commun. 2022. PMID: 35145068 Free PMC article.

9

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.

Dobson CL, Devine PW, Phillips JJ, Higazi DR, Lloyd C, Popovic B, Arnold J, Buchanan A, Lewis A, Goodman J, van der Walle CF, Thornton P, Vinall L, Lowne D, Aagaard A, Olsson LL, Ridderstad Wollberg A, Welsh F, Karamanos TK, Pashley CL, Iadanza MG, Ranson NA, Ashcroft AE, Kippen AD, Vaughan TJ, Radford SE, Lowe DC. Dobson CL, et al. Among authors: phillips jj. Sci Rep. 2016 Dec 20;6:38644. doi: 10.1038/srep38644. Sci Rep. 2016. PMID: 27995962 Free PMC article.

10

Online Fully Automated System for Hydrogen/Deuterium-Exchange Mass Spectrometry with Millisecond Time Resolution.

Kish M, Smith V, Lethbridge N, Cole L, Bond NJ, Phillips JJ. Kish M, et al. Among authors: phillips jj. Anal Chem. 2023 Mar 21;95(11):5000-5008. doi: 10.1021/acs.analchem.2c05310. Epub 2023 Mar 9. Anal Chem. 2023. PMID: 36896500 Free PMC article.

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