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A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.
Deyaert E, Wauters L, Guaitoli G, Konijnenberg A, Leemans M, Terheyden S, Petrovic A, Gallardo R, Nederveen-Schippers LM, Athanasopoulos PS, Pots H, Van Haastert PJM, Sobott F, Gloeckner CJ, Efremov R, Kortholt A, Versées W. Deyaert E, et al. Among authors: sobott f. Nat Commun. 2017 Oct 18;8(1):1008. doi: 10.1038/s41467-017-01103-4. Nat Commun. 2017. PMID: 29044096 Free PMC article.
Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure.
Ponzini E, De Palma A, Cerboni L, Natalello A, Rossi R, Moons R, Konijnenberg A, Narkiewicz J, Legname G, Sobott F, Mauri P, Santambrogio C, Grandori R. Ponzini E, et al. Among authors: sobott f. J Biol Chem. 2019 Apr 5;294(14):5657-5665. doi: 10.1074/jbc.RA118.001907. Epub 2019 Feb 12. J Biol Chem. 2019. PMID: 30755483 Free PMC article.
Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity.
Daniels MJ, Nourse JB Jr, Kim H, Sainati V, Schiavina M, Murrali MG, Pan B, Ferrie JJ, Haney CM, Moons R, Gould NS, Natalello A, Grandori R, Sobott F, Petersson EJ, Rhoades E, Pierattelli R, Felli I, Uversky VN, Caldwell KA, Caldwell GA, Krol ES, Ischiropoulos H. Daniels MJ, et al. Among authors: sobott f. Sci Rep. 2019 Feb 27;9(1):2937. doi: 10.1038/s41598-019-39480-z. Sci Rep. 2019. PMID: 30814575 Free PMC article.
Metal ions shape α-synuclein.
Moons R, Konijnenberg A, Mensch C, Van Elzen R, Johannessen C, Maudsley S, Lambeir AM, Sobott F. Moons R, et al. Among authors: sobott f. Sci Rep. 2020 Oct 1;10(1):16293. doi: 10.1038/s41598-020-73207-9. Sci Rep. 2020. PMID: 33004902 Free PMC article.
156 results