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Targeting SHP2 phosphatase in hematological malignancies.
Kanumuri R, Kumar Pasupuleti S, Burns SS, Ramdas B, Kapur R. Kanumuri R, et al. Among authors: burns ss. Expert Opin Ther Targets. 2022 Apr;26(4):319-332. doi: 10.1080/14728222.2022.2066518. Epub 2022 May 3. Expert Opin Ther Targets. 2022. PMID: 35503226 Free PMC article. Review.
Il-1r1 drives leukemogenesis induced by Tet2 loss.
Burns SS, Kumar R, Pasupuleti SK, So K, Zhang C, Kapur R. Burns SS, et al. Leukemia. 2022 Oct;36(10):2531-2534. doi: 10.1038/s41375-022-01665-3. Epub 2022 Aug 12. Leukemia. 2022. PMID: 35962058 Free PMC article. No abstract available.
Obesity-induced inflammation exacerbates clonal hematopoiesis.
Pasupuleti SK, Ramdas B, Burns SS, Palam LR, Kanumuri R, Kumar R, Pandhiri TR, Dave UP, Yellapu NK, Zhou X, Zhang C, Sandusky GE, Yu Z, Honigberg MC, Bick AG, Griffin GK, Niroula A, Ebert BL, Paczesny S, Natarajan P, Kapur R. Pasupuleti SK, et al. Among authors: burns ss. J Clin Invest. 2023 Jun 1;133(11):e163968. doi: 10.1172/JCI163968. J Clin Invest. 2023. PMID: 37071471 Free PMC article.
Early phase clinical studies of AR-42, a histone deacetylase inhibitor, for neurofibromatosis type 2-associated vestibular schwannomas and meningiomas.
Welling DB, Collier KA, Burns SS, Oblinger JL, Shu E, Miles-Markley BA, Hofmeister CC, Makary MS, Slone HW, Blakeley JO, Mansouri SA, Neff BA, Jackler RK, Mortazavi A, Chang LS. Welling DB, et al. Among authors: burns ss. Laryngoscope Investig Otolaryngol. 2021 Aug 20;6(5):1008-1019. doi: 10.1002/lio2.643. eCollection 2021 Oct. Laryngoscope Investig Otolaryngol. 2021. PMID: 34667843 Free PMC article.
Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK.
Chang LS, Oblinger JL, Smith AE, Ferrer M, Angus SP, Hawley E, Petrilli AM, Beauchamp RL, Riecken LB, Erdin S, Poi M, Huang J, Bessler WK, Zhang X, Guha R, Thomas C, Burns SS, Gilbert TSK, Jiang L, Li X, Lu Q, Yuan J, He Y, Dixon SAH, Masters A, Jones DR, Yates CW, Haggarty SJ, La Rosa S, Welling DB, Stemmer-Rachamimov AO, Plotkin SR, Gusella JF, Guinney J, Morrison H, Ramesh V, Fernandez-Valle C, Johnson GL, Blakeley JO, Clapp DW; Synodos for NF2 Consortium. Chang LS, et al. Among authors: burns ss. PLoS One. 2021 Jul 15;16(7):e0252048. doi: 10.1371/journal.pone.0252048. eCollection 2021. PLoS One. 2021. PMID: 34264955 Free PMC article.
26 results