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Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs.
Do C, Dumont ELP, Salas M, Castano A, Mujahed H, Maldonado L, Singh A, DaSilva-Arnold SC, Bhagat G, Lehman S, Christiano AM, Madhavan S, Nagy PL, Green PHR, Feinman R, Trimble C, Illsley NP, Marder K, Honig L, Monk C, Goy A, Chow K, Goldlust S, Kaptain G, Siegel D, Tycko B. Do C, et al. Among authors: tycko b. Genome Biol. 2020 Jun 29;21(1):153. doi: 10.1186/s13059-020-02059-3. Genome Biol. 2020. PMID: 32594908 Free PMC article.
Placental growth retardation due to loss of imprinting of Phlda2.
Salas M, John R, Saxena A, Barton S, Frank D, Fitzpatrick G, Higgins MJ, Tycko B. Salas M, et al. Among authors: tycko b. Mech Dev. 2004 Oct;121(10):1199-210. doi: 10.1016/j.mod.2004.05.017. Mech Dev. 2004. PMID: 15327781 Free article.
PEG10 is a c-MYC target gene in cancer cells.
Li CM, Margolin AA, Salas M, Memeo L, Mansukhani M, Hibshoosh H, Szabolcs M, Klinakis A, Tycko B. Li CM, et al. Among authors: tycko b. Cancer Res. 2006 Jan 15;66(2):665-72. doi: 10.1158/0008-5472.CAN-05-1553. Cancer Res. 2006. PMID: 16423995
Global hypomethylation of genomic DNA in cancer-associated myofibroblasts.
Jiang L, Gonda TA, Gamble MV, Salas M, Seshan V, Tu S, Twaddell WS, Hegyi P, Lazar G, Steele I, Varro A, Wang TC, Tycko B. Jiang L, et al. Among authors: tycko b. Cancer Res. 2008 Dec 1;68(23):9900-8. doi: 10.1158/0008-5472.CAN-08-1319. Cancer Res. 2008. PMID: 19047171 Free PMC article.
Altered DNA methylation in leukocytes with trisomy 21.
Kerkel K, Schupf N, Hatta K, Pang D, Salas M, Kratz A, Minden M, Murty V, Zigman WB, Mayeux RP, Jenkins EC, Torkamani A, Schork NJ, Silverman W, Croy BA, Tycko B. Kerkel K, et al. Among authors: tycko b. PLoS Genet. 2010 Nov 18;6(11):e1001212. doi: 10.1371/journal.pgen.1001212. PLoS Genet. 2010. PMID: 21124956 Free PMC article.
188 results