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Impairment of Flow-Sensitive Inwardly Rectifying K+ Channels via Disruption of Glycocalyx Mediates Obesity-Induced Endothelial Dysfunction.
Fancher IS, Le Master E, Ahn SJ, Adamos C, Lee JC, Berdyshev E, Dull RO, Phillips SA, Levitan I. Fancher IS, et al. Among authors: levitan i. Arterioscler Thromb Vasc Biol. 2020 Sep;40(9):e240-e255. doi: 10.1161/ATVBAHA.120.314935. Epub 2020 Jul 23. Arterioscler Thromb Vasc Biol. 2020. PMID: 32698687 Free PMC article.
Cholesterol and Kir channels.
Levitan I. Levitan I. IUBMB Life. 2009 Aug;61(8):781-90. doi: 10.1002/iub.192. IUBMB Life. 2009. PMID: 19548316 Free PMC article. Review.
Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).
Rosenhouse-Dantsker A, Noskov S, Han H, Adney SK, Tang QY, Rodríguez-Menchaca AA, Kowalsky GB, Petrou VI, Osborn CV, Logothetis DE, Levitan I. Rosenhouse-Dantsker A, et al. Among authors: levitan i. J Biol Chem. 2012 Nov 23;287(48):40266-78. doi: 10.1074/jbc.M111.336339. Epub 2012 Sep 20. J Biol Chem. 2012. PMID: 22995912 Free PMC article.
Silencing of Kir2 channels by caveolin-1: cross-talk with cholesterol.
Han H, Rosenhouse-Dantsker A, Gnanasambandam R, Epshtein Y, Chen Z, Sachs F, Minshall RD, Levitan I. Han H, et al. Among authors: levitan i. J Physiol. 2014 Sep 15;592(18):4025-38. doi: 10.1113/jphysiol.2014.273177. Epub 2014 Jul 18. J Physiol. 2014. PMID: 25038242 Free PMC article.
Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins.
Le Master E, Huang RT, Zhang C, Bogachkov Y, Coles C, Shentu TP, Sheng Y, Fancher IS, Ng C, Christoforidis T, Subbaiah PV, Berdyshev E, Qain Z, Eddington DT, Lee J, Cho M, Fang Y, Minshall RD, Levitan I. Le Master E, et al. Among authors: levitan i. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):64-75. doi: 10.1161/ATVBAHA.117.309907. Epub 2017 Oct 12. Arterioscler Thromb Vasc Biol. 2018. PMID: 29025707 Free PMC article.
271 results