Nigsch F - Search Results

1

Systematic Chemogenetic Library Assembly.

Canham SM, Wang Y, Cornett A, Auld DS, Baeschlin DK, Patoor M, Skaanderup PR, Honda A, Llamas L, Wendel G, Mapa FA, Aspesi P Jr, Labbé-Giguère N, Gamber GG, Palacios DS, Schuffenhauer A, Deng Z, Nigsch F, Frederiksen M, Bushell SM, Rothman D, Jain RK, Hemmerle H, Briner K, Porter JA, Tallarico JA, Jenkins JL. Canham SM, et al. Among authors: nigsch f. Cell Chem Biol. 2020 Sep 17;27(9):1124-1129. doi: 10.1016/j.chembiol.2020.07.004. Epub 2020 Jul 23. Cell Chem Biol. 2020. PMID: 32707038 Free article. Review.

2

Ligand-target prediction using Winnow and naive Bayesian algorithms and the implications of overall performance statistics.

Nigsch F, Bender A, Jenkins JL, Mitchell JB. Nigsch F, et al. J Chem Inf Model. 2008 Dec;48(12):2313-25. doi: 10.1021/ci800079x. J Chem Inf Model. 2008. PMID: 19055411

3

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.

Sukuru SC, Nigsch F, Quancard J, Renatus M, Chopra R, Brooijmans N, Mikhailov D, Deng Z, Cornett A, Jenkins JL, Hommel U, Davies JW, Glick M. Sukuru SC, et al. Among authors: nigsch f. Protein Sci. 2010 Nov;19(11):2096-109. doi: 10.1002/pro.490. Protein Sci. 2010. PMID: 20799349 Free PMC article.

4

Recent trends and observations in the design of high-quality screening collections.

Renner S, Popov M, Schuffenhauer A, Roth HJ, Breitenstein W, Marzinzik A, Lewis I, Krastel P, Nigsch F, Jenkins J, Jacoby E. Renner S, et al. Among authors: nigsch f. Future Med Chem. 2011 Apr;3(6):751-66. doi: 10.4155/fmc.11.15. Future Med Chem. 2011. PMID: 21554080 Review.

5

Computational methods for early predictive safety assessment from biological and chemical data.

Nigsch F, Lounkine E, McCarren P, Cornett B, Glick M, Azzaoui K, Urban L, Marc P, Müller A, Hahne F, Heard DJ, Jenkins JL. Nigsch F, et al. Expert Opin Drug Metab Toxicol. 2011 Dec;7(12):1497-511. doi: 10.1517/17425255.2011.632632. Epub 2011 Nov 4. Expert Opin Drug Metab Toxicol. 2011. PMID: 22050465 Review.

6

Activity-aware clustering of high throughput screening data and elucidation of orthogonal structure-activity relationships.

Lounkine E, Nigsch F, Jenkins JL, Glick M. Lounkine E, et al. Among authors: nigsch f. J Chem Inf Model. 2011 Dec 27;51(12):3158-68. doi: 10.1021/ci2004994. Epub 2011 Dec 7. J Chem Inf Model. 2011. PMID: 22098146

7

Determination of minimal transcriptional signatures of compounds for target prediction.

Nigsch F, Hutz J, Cornett B, Selinger DW, McAllister G, Bandyopadhyay S, Loureiro J, Jenkins JL. Nigsch F, et al. EURASIP J Bioinform Syst Biol. 2012 May 10;2012(1):2. doi: 10.1186/1687-4153-2012-2. EURASIP J Bioinform Syst Biol. 2012. PMID: 22574917 Free PMC article.

8

Rethinking molecular similarity: comparing compounds on the basis of biological activity.

Petrone PM, Simms B, Nigsch F, Lounkine E, Kutchukian P, Cornett A, Deng Z, Davies JW, Jenkins JL, Glick M. Petrone PM, et al. Among authors: nigsch f. ACS Chem Biol. 2012 Aug 17;7(8):1399-409. doi: 10.1021/cb3001028. Epub 2012 May 31. ACS Chem Biol. 2012. PMID: 22594495

9

The multidimensional perturbation value: a single metric to measure similarity and activity of treatments in high-throughput multidimensional screens.

Hutz JE, Nelson T, Wu H, McAllister G, Moutsatsos I, Jaeger SA, Bandyopadhyay S, Nigsch F, Cornett B, Jenkins JL, Selinger DW. Hutz JE, et al. Among authors: nigsch f. J Biomol Screen. 2013 Apr;18(4):367-77. doi: 10.1177/1087057112469257. Epub 2012 Nov 29. J Biomol Screen. 2013. PMID: 23204073

10

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.

Hoepfner D, Helliwell SB, Sadlish H, Schuierer S, Filipuzzi I, Brachat S, Bhullar B, Plikat U, Abraham Y, Altorfer M, Aust T, Baeriswyl L, Cerino R, Chang L, Estoppey D, Eichenberger J, Frederiksen M, Hartmann N, Hohendahl A, Knapp B, Krastel P, Melin N, Nigsch F, Oakeley EJ, Petitjean V, Petersen F, Riedl R, Schmitt EK, Staedtler F, Studer C, Tallarico JA, Wetzel S, Fishman MC, Porter JA, Movva NR. Hoepfner D, et al. Among authors: nigsch f. Microbiol Res. 2014 Feb-Mar;169(2-3):107-20. doi: 10.1016/j.micres.2013.11.004. Epub 2013 Dec 1. Microbiol Res. 2014. PMID: 24360837 Free article.

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