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Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes.
Uchida Y, Hasegawa J, Chinnapen D, Inoue T, Okazaki S, Kato R, Wakatsuki S, Misaki R, Koike M, Uchiyama Y, Iemura S, Natsume T, Kuwahara R, Nakagawa T, Nishikawa K, Mukai K, Miyoshi E, Taniguchi N, Sheff D, Lencer WI, Taguchi T, Arai H. Uchida Y, et al. Among authors: mukai k. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15846-51. doi: 10.1073/pnas.1109101108. Epub 2011 Sep 12. Proc Natl Acad Sci U S A. 2011. PMID: 21911378 Free PMC article.
Activation of STING requires palmitoylation at the Golgi.
Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, Barber GN, Arai H, Taguchi T. Mukai K, et al. Nat Commun. 2016 Jun 21;7:11932. doi: 10.1038/ncomms11932. Nat Commun. 2016. PMID: 27324217 Free PMC article.
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
Hansen AL, Buchan GJ, Rühl M, Mukai K, Salvatore SR, Ogawa E, Andersen SD, Iversen MB, Thielke AL, Gunderstofte C, Motwani M, Møller CT, Jakobsen AS, Fitzgerald KA, Roos J, Lin R, Maier TJ, Goldbach-Mansky R, Miner CA, Qian W, Miner JJ, Rigby RE, Rehwinkel J, Jakobsen MR, Arai H, Taguchi T, Schopfer FJ, Olagnier D, Holm CK. Hansen AL, et al. Among authors: mukai k. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7768-E7775. doi: 10.1073/pnas.1806239115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061387 Free PMC article.
STING palmitoylation as a therapeutic target.
Hansen AL, Mukai K, Schopfer FJ, Taguchi T, Holm CK. Hansen AL, et al. Among authors: mukai k. Cell Mol Immunol. 2019 Mar;16(3):236-241. doi: 10.1038/s41423-019-0205-5. Epub 2019 Feb 22. Cell Mol Immunol. 2019. PMID: 30796349 Free PMC article. Review.
Innate immunity signalling and membrane trafficking.
Taguchi T, Mukai K. Taguchi T, et al. Among authors: mukai k. Curr Opin Cell Biol. 2019 Aug;59:1-7. doi: 10.1016/j.ceb.2019.02.002. Epub 2019 Mar 12. Curr Opin Cell Biol. 2019. PMID: 30875551 Free article. Review.
FAM48A mediates compensatory autophagy induced by proteasome impairment.
Arata Y, Watanabe A, Motosugi R, Iemura SI, Natsume T, Mukai K, Taguchi T, Hirayama S, Hamazaki J, Murata S. Arata Y, et al. Among authors: mukai k. Genes Cells. 2019 Aug;24(8):559-568. doi: 10.1111/gtc.12708. Epub 2019 Jul 3. Genes Cells. 2019. PMID: 31210371 Free article.
STING Operation at the ER/Golgi Interface.
Taguchi T, Mukai K, Takaya E, Shindo R. Taguchi T, et al. Among authors: mukai k. Front Immunol. 2021 May 3;12:646304. doi: 10.3389/fimmu.2021.646304. eCollection 2021. Front Immunol. 2021. PMID: 34012437 Free PMC article. Review.
1,098 results