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Combined Proteomic and Genetic Interaction Mapping Reveals New RAS Effector Pathways and Susceptibilities.
Cancer Discov. 2020 Dec;10(12):1950-1967. doi: 10.1158/2159-8290.CD-19-1274. Epub 2020 Jul 29.
Cancer Discov. 2020.
PMID: 32727735
Free PMC article.
Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase.
Gwinn DM, Lee AG, Briones-Martin-Del-Campo M, Conn CS, Simpson DR, Scott AI, Le A, Cowan TM, Ruggero D, Sweet-Cordero EA.
Gwinn DM, et al.
Cancer Cell. 2018 Jan 8;33(1):91-107.e6. doi: 10.1016/j.ccell.2017.12.003.
Cancer Cell. 2018.
PMID: 29316436
Free PMC article.
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The phosphatase PP2A links glutamine to the tumor suppressor p53.
Gwinn D, Sweet-Cordero EA.
Gwinn D, et al.
Mol Cell. 2013 Apr 25;50(2):157-8. doi: 10.1016/j.molcel.2013.04.010.
Mol Cell. 2013.
PMID: 23622513
Free article.
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An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.
Vallejo A, Perurena N, Guruceaga E, Mazur PK, Martinez-Canarias S, Zandueta C, Valencia K, Arricibita A, Gwinn D, Sayles LC, Chuang CH, Guembe L, Bailey P, Chang DK, Biankin A, Ponz-Sarvise M, Andersen JB, Khatri P, Bozec A, Sweet-Cordero EA, Sage J, Lecanda F, Vicent S.
Vallejo A, et al.
Nat Commun. 2017 Feb 21;8:14294. doi: 10.1038/ncomms14294.
Nat Commun. 2017.
PMID: 28220783
Free PMC article.
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AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ.
Gwinn DM, et al.
Mol Cell. 2008 Apr 25;30(2):214-26. doi: 10.1016/j.molcel.2008.03.003.
Mol Cell. 2008.
PMID: 18439900
Free PMC article.
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Raptor is phosphorylated by cdc2 during mitosis.
Gwinn DM, Asara JM, Shaw RJ.
Gwinn DM, et al.
PLoS One. 2010 Feb 12;5(2):e9197. doi: 10.1371/journal.pone.0009197.
PLoS One. 2010.
PMID: 20169205
Free PMC article.
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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ.
Egan DF, et al. Among authors: gwinn dm.
Science. 2011 Jan 28;331(6016):456-61. doi: 10.1126/science.1196371. Epub 2010 Dec 23.
Science. 2011.
PMID: 21205641
Free PMC article.
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Resveratrol improves health and survival of mice on a high-calorie diet.
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA.
Baur JA, et al.
Nature. 2006 Nov 16;444(7117):337-42. doi: 10.1038/nature05354. Epub 2006 Nov 1.
Nature. 2006.
PMID: 17086191
Free PMC article.
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