Ormsby AR - Search Results

1

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA.

Ormsby AR, Cox D, Daly J, Priest D, Hinde E, Hatters DM. Ormsby AR, et al. PLoS One. 2020 Jul 31;15(7):e0233583. doi: 10.1371/journal.pone.0233583. eCollection 2020. PLoS One. 2020. PMID: 32735619 Free PMC article.

2

Tracking protein aggregation and mislocalization in cells with flow cytometry.

Ramdzan YM, Polling S, Chia CP, Ng IH, Ormsby AR, Croft NP, Purcell AW, Bogoyevitch MA, Ng DC, Gleeson PA, Hatters DM. Ramdzan YM, et al. Among authors: ormsby ar. Nat Methods. 2012 Mar 18;9(5):467-70. doi: 10.1038/nmeth.1930. Nat Methods. 2012. PMID: 22426490

3

Tyrosine 416 is phosphorylated in the closed, repressed conformation of c-Src.

Irtegun S, Wood RJ, Ormsby AR, Mulhern TD, Hatters DM. Irtegun S, et al. Among authors: ormsby ar. PLoS One. 2013 Jul 26;8(7):e71035. doi: 10.1371/journal.pone.0071035. Print 2013. PLoS One. 2013. PMID: 23923048 Free PMC article.

4

A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70.

Ormsby AR, Ramdzan YM, Mok YF, Jovanoski KD, Hatters DM. Ormsby AR, et al. J Biol Chem. 2013 Dec 27;288(52):37192-203. doi: 10.1074/jbc.M113.486944. Epub 2013 Nov 6. J Biol Chem. 2013. PMID: 24196953 Free PMC article.

5

Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation.

Polling S, Ormsby AR, Wood RJ, Lee K, Shoubridge C, Hughes JN, Thomas PQ, Griffin MD, Hill AF, Bowden Q, Böcking T, Hatters DM. Polling S, et al. Among authors: ormsby ar. Nat Struct Mol Biol. 2015 Dec;22(12):1008-15. doi: 10.1038/nsmb.3127. Epub 2015 Nov 16. Nat Struct Mol Biol. 2015. PMID: 26571108

6

Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells.

Büning S, Sharma A, Vachharajani S, Newcombe E, Ormsby A, Gao M, Gnutt D, Vöpel T, Hatters DM, Ebbinghaus S. Büning S, et al. Phys Chem Chem Phys. 2017 May 3;19(17):10738-10747. doi: 10.1039/c6cp08167c. Phys Chem Chem Phys. 2017. PMID: 28094373

7

N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion.

Chen MZ, Mok SA, Ormsby AR, Muchowski PJ, Hatters DM. Chen MZ, et al. Among authors: ormsby ar. J Huntingtons Dis. 2017;6(1):79-91. doi: 10.3233/JHD-160207. J Huntingtons Dis. 2017. PMID: 28339398

8

Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.

Ramdzan YM, Trubetskov MM, Ormsby AR, Newcombe EA, Sui X, Tobin MJ, Bongiovanni MN, Gras SL, Dewson G, Miller JML, Finkbeiner S, Moily NS, Niclis J, Parish CL, Purcell AW, Baker MJ, Wilce JA, Waris S, Stojanovski D, Böcking T, Ang CS, Ascher DB, Reid GE, Hatters DM. Ramdzan YM, et al. Among authors: ormsby ar. Cell Rep. 2017 May 2;19(5):919-927. doi: 10.1016/j.celrep.2017.04.029. Cell Rep. 2017. PMID: 28467905 Free article.

9

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.

Moily NS, Ormsby AR, Stojilovic A, Ramdzan YM, Diesch J, Hannan RD, Zajac MS, Hannan AJ, Oshlack A, Hatters DM. Moily NS, et al. Among authors: ormsby ar. Mol Cell Neurosci. 2017 Sep;83:103-112. doi: 10.1016/j.mcn.2017.07.004. Epub 2017 Jul 23. Mol Cell Neurosci. 2017. PMID: 28743452

10

A biosensor-based framework to measure latent proteostasis capacity.

Wood RJ, Ormsby AR, Radwan M, Cox D, Sharma A, Vöpel T, Ebbinghaus S, Oliveberg M, Reid GE, Dickson A, Hatters DM. Wood RJ, et al. Among authors: ormsby ar. Nat Commun. 2018 Jan 18;9(1):287. doi: 10.1038/s41467-017-02562-5. Nat Commun. 2018. PMID: 29348634 Free PMC article.

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