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Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects.
Lombardo M, Bender K, London C, Plotkin MA, Kirkland M, Mane J, Pachanski M, Geissler W, Cummings J, Habulihaz B, Akiyama TE, Di Salvo J, Madeira M, Pols J, Powles MA, Finley MF, Johnson E, Roussel T, Uebele VN, Crespo A, Leung D, Alleyne C, Trusca D, Lei Y, Howard AD, Ujjainwalla F, Tata JR, Sinz CJ. Lombardo M, et al. Among authors: finley mf. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5724-5728. doi: 10.1016/j.bmcl.2016.10.054. Epub 2016 Oct 24. Bioorg Med Chem Lett. 2016. PMID: 27815121
Corrigendum to "Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects" [Bioorg. Med. Chem. Lett. 26 (2016) 5724-5728].
Lombardo M, Bender K, London C, Plotkin MA, Kirkland M, Mane J, Pachanski M, Geissler W, Cummings J, Habulihaz B, Akiyama TE, Di Salvo J, Madeira M, Pols J, Powles MA, Finley MF, Johnson E, Roussel T, Uebele VN, Crespo A, Leung D, Alleyne C, Trusca D, Lei Y, Howard AD, Ujjainwalla F, Tata JR, Sinz CJ. Lombardo M, et al. Among authors: finley mf. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1333. doi: 10.1016/j.bmcl.2017.01.082. Epub 2017 Feb 4. Bioorg Med Chem Lett. 2017. PMID: 28169160 No abstract available.
Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score.
Pertusi DA, O'Donnell G, Homsher MF, Solly K, Patel A, Stahler SL, Riley D, Finley MF, Finger EN, Adam GC, Meng J, Bell DJ, Zuck PD, Hudak EM, Weber MJ, Nothstein JE, Locco L, Quinn C, Amoss A, Squadroni B, Hartnett M, Heo MR, White T, May SA, Boots E, Roberts K, Cocchiarella P, Wolicki A, Kreamer A, Kutchukian PS, Wassermann AM, Uebele VN, Glick M, Rusinko A 3rd, Culberson JC. Pertusi DA, et al. Among authors: finley mf. SLAS Discov. 2017 Sep;22(8):995-1006. doi: 10.1177/2472555217706058. Epub 2017 Apr 20. SLAS Discov. 2017. PMID: 28426940 Free article.
Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain.
Wall MJ, Subasinghe NL, Winters MP, Lubin ML, Finley MFA, Qin N, Brandt MR, Neeper MP, Schneider CR, Colburn RW, Flores CM, Sui Z. Wall MJ, et al. Among authors: finley mfa. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3780-3783. doi: 10.1016/j.bmcl.2018.10.007. Epub 2018 Oct 12. Bioorg Med Chem Lett. 2018. PMID: 30337231
A novel series of pyrazolylpiperidine N-type calcium channel blockers.
Subasinghe NL, Wall MJ, Winters MP, Qin N, Lubin ML, Finley MF, Brandt MR, Neeper MP, Schneider CR, Colburn RW, Flores CM, Sui Z. Subasinghe NL, et al. Among authors: finley mf. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4080-3. doi: 10.1016/j.bmcl.2012.04.075. Epub 2012 May 2. Bioorg Med Chem Lett. 2012. PMID: 22608964
Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep).
Parsons WH, Calvo RR, Cheung W, Lee YK, Patel S, Liu J, Youngman MA, Dax SL, Stone D, Qin N, Hutchinson T, Lubin ML, Zhang SP, Finley M, Liu Y, Brandt MR, Flores CM, Player MR. Parsons WH, et al. Among authors: finley m. J Med Chem. 2015 May 14;58(9):3859-74. doi: 10.1021/acs.jmedchem.5b00132. Epub 2015 Apr 15. J Med Chem. 2015. PMID: 25850459
157 results