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A small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy.
Amgalan D, Garner TP, Pekson R, Jia XF, Yanamandala M, Paulino V, Liang FG, Corbalan JJ, Lee J, Chen Y, Karagiannis GS, Sanchez LR, Liang H, Narayanagari SR, Mitchell K, Lopez A, Margulets V, Scarlata M, Santulli G, Asnani A, Peterson RT, Hazan RB, Condeelis JS, Oktay MH, Steidl U, Kirshenbaum LA, Gavathiotis E, Kitsis RN. Amgalan D, et al. Among authors: kitsis rn. Nat Cancer. 2020 Mar;1(3):315-328. doi: 10.1038/s43018-020-0039-1. Epub 2020 Mar 2. Nat Cancer. 2020. PMID: 32776015 Free PMC article.
Bax regulates primary necrosis through mitochondrial dynamics.
Whelan RS, Konstantinidis K, Wei AC, Chen Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T, Thompson CB, Crow MT, Gavathiotis E, Dorn GW 2nd, O'Rourke B, Kitsis RN. Whelan RS, et al. Among authors: kitsis rn. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6566-71. doi: 10.1073/pnas.1201608109. Epub 2012 Apr 9. Proc Natl Acad Sci U S A. 2012. PMID: 22493254 Free PMC article.
Recent progress in research on molecular mechanisms of autophagy in the heart.
Maejima Y, Chen Y, Isobe M, Gustafsson ÅB, Kitsis RN, Sadoshima J. Maejima Y, et al. Among authors: kitsis rn. Am J Physiol Heart Circ Physiol. 2015 Feb 15;308(4):H259-68. doi: 10.1152/ajpheart.00711.2014. Epub 2014 Nov 14. Am J Physiol Heart Circ Physiol. 2015. PMID: 25398984 Free PMC article. Review.
Correcting mitochondrial fusion by manipulating mitofusin conformations.
Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW II. Franco A, et al. Among authors: kitsis rn. Nature. 2016 Dec 1;540(7631):74-79. doi: 10.1038/nature20156. Epub 2016 Oct 24. Nature. 2016. PMID: 27775718 Free PMC article.
A myeloid tumor suppressor role for NOL3.
Stanley RF, Piszczatowski RT, Bartholdy B, Mitchell K, McKimpson WM, Narayanagari S, Walter D, Todorova TI, Hirsch C, Makishima H, Will B, McMahon C, Gritsman K, Maciejewski JP, Kitsis RN, Steidl U. Stanley RF, et al. Among authors: kitsis rn. J Exp Med. 2017 Mar 6;214(3):753-771. doi: 10.1084/jem.20162089. Epub 2017 Feb 23. J Exp Med. 2017. PMID: 28232469 Free PMC article.
Grounding Cardio-Oncology in Basic and Clinical Science.
Moslehi J, Amgalan D, Kitsis RN. Moslehi J, et al. Among authors: kitsis rn. Circulation. 2017 Jul 4;136(1):3-5. doi: 10.1161/CIRCULATIONAHA.117.025393. Circulation. 2017. PMID: 28674089 Free PMC article. No abstract available.
141 results