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19 results

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Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity.
Smeby J, Kryeziu K, Berg KCG, Eilertsen IA, Eide PW, Johannessen B, Guren MG, Nesbakken A, Bruun J, Lothe RA, Sveen A. Smeby J, et al. Among authors: eide pw. EBioMedicine. 2020 Sep;59:102923. doi: 10.1016/j.ebiom.2020.102923. Epub 2020 Aug 13. EBioMedicine. 2020. PMID: 32799124 Free PMC article.
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies.
Berg KCG, Eide PW, Eilertsen IA, Johannessen B, Bruun J, Danielsen SA, Bjørnslett M, Meza-Zepeda LA, Eknæs M, Lind GE, Myklebost O, Skotheim RI, Sveen A, Lothe RA. Berg KCG, et al. Among authors: eide pw. Mol Cancer. 2017 Jul 6;16(1):116. doi: 10.1186/s12943-017-0691-y. Mol Cancer. 2017. PMID: 28683746 Free PMC article.
Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies.
Sveen A, Bruun J, Eide PW, Eilertsen IA, Ramirez L, Murumägi A, Arjama M, Danielsen SA, Kryeziu K, Elez E, Tabernero J, Guinney J, Palmer HG, Nesbakken A, Kallioniemi O, Dienstmann R, Lothe RA. Sveen A, et al. Among authors: eide pw. Clin Cancer Res. 2018 Feb 15;24(4):794-806. doi: 10.1158/1078-0432.CCR-17-1234. Epub 2017 Dec 14. Clin Cancer Res. 2018. PMID: 29242316
Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity.
Bruun J, Kryeziu K, Eide PW, Moosavi SH, Eilertsen IA, Langerud J, Røsok B, Totland MZ, Brunsell TH, Pellinen T, Saarela J, Bergsland CH, Palmer HG, Brudvik KW, Guren T, Dienstmann R, Guren MG, Nesbakken A, Bjørnbeth BA, Sveen A, Lothe RA. Bruun J, et al. Among authors: eide pw. Clin Cancer Res. 2020 Aug 1;26(15):4107-4119. doi: 10.1158/1078-0432.CCR-19-3637. Epub 2020 Apr 16. Clin Cancer Res. 2020. PMID: 32299813
The expressed mutational landscape of microsatellite stable colorectal cancers.
Sveen A, Johannessen B, Eilertsen IA, Røsok BI, Gulla M, Eide PW, Bruun J, Kryeziu K, Meza-Zepeda LA, Myklebost O, Bjørnbeth BA, Skotheim RI, Nesbakken A, Lothe RA. Sveen A, et al. Among authors: eide pw. Genome Med. 2021 Sep 1;13(1):142. doi: 10.1186/s13073-021-00955-2. Genome Med. 2021. PMID: 34470667 Free PMC article.
E-cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora, and HSP90 in preclinical models.
Bruun J, Eide PW, Bergsland CH, Bruck O, Svindland A, Arjama M, Välimäki K, Bjørnslett M, Guren MG, Kallioniemi O, Nesbakken A, Lothe RA, Pellinen T. Bruun J, et al. Among authors: eide pw. Mol Oncol. 2022 Jun;16(12):2312-2329. doi: 10.1002/1878-0261.13159. Epub 2021 Dec 26. Mol Oncol. 2022. PMID: 34890102 Free PMC article.
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