Yang Y - Search Results

1

Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite.

Perez M, Bak DW, Bergholtz SE, Crooks DR, Arimilli BS, Yang Y, Weerapana E, Linehan WM, Meier JL. Perez M, et al. Among authors: yang y. J Biol Chem. 2020 Sep 25;295(39):13410-13418. doi: 10.1074/jbc.AC120.014993. Epub 2020 Aug 19. J Biol Chem. 2020. PMID: 32820045 Free PMC article.

2

Co-opting a Bioorthogonal Reaction for Oncometabolite Detection.

Zengeya TT, Garlick JM, Kulkarni RA, Miley M, Roberts AM, Yang Y, Crooks DR, Sourbier C, Linehan WM, Meier JL. Zengeya TT, et al. Among authors: yang y. J Am Chem Soc. 2016 Dec 14;138(49):15813-15816. doi: 10.1021/jacs.6b09706. Epub 2016 Nov 30. J Am Chem Soc. 2016. PMID: 27960310 Free PMC article.

3

Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma.

Sourbier C, Valera-Romero V, Giubellino A, Yang Y, Sudarshan S, Neckers L, Linehan WM. Sourbier C, et al. Among authors: yang y. Cell Cycle. 2010 Oct 15;9(20):4183-9. doi: 10.4161/cc.9.20.13458. Epub 2010 Oct 27. Cell Cycle. 2010. PMID: 20953139 Free PMC article.

4

A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer.

Yang Y, Valera V, Sourbier C, Vocke CD, Wei M, Pike L, Huang Y, Merino MA, Bratslavsky G, Wu M, Ricketts CJ, Linehan WM. Yang Y, et al. Cancer Genet. 2012 Jul-Aug;205(7-8):377-90. doi: 10.1016/j.cancergen.2012.05.001. Cancer Genet. 2012. PMID: 22867999 Free PMC article.

5

Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma.

Yang Y, Lane AN, Ricketts CJ, Sourbier C, Wei MH, Shuch B, Pike L, Wu M, Rouault TA, Boros LG, Fan TW, Linehan WM. Yang Y, et al. PLoS One. 2013 Aug 15;8(8):e72179. doi: 10.1371/journal.pone.0072179. eCollection 2013. PLoS One. 2013. PMID: 23967283 Free PMC article.

6

Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.

Sourbier C, Ricketts CJ, Matsumoto S, Crooks DR, Liao PJ, Mannes PZ, Yang Y, Wei MH, Srivastava G, Ghosh S, Chen V, Vocke CD, Merino M, Srinivasan R, Krishna MC, Mitchell JB, Pendergast AM, Rouault TA, Neckers L, Linehan WM. Sourbier C, et al. Among authors: yang y. Cancer Cell. 2014 Dec 8;26(6):840-850. doi: 10.1016/j.ccell.2014.10.005. Cancer Cell. 2014. PMID: 25490448 Free PMC article.

7

Comprehensive genomic and phenotypic characterization of germline FH deletion in hereditary leiomyomatosis and renal cell carcinoma.

Vocke CD, Ricketts CJ, Merino MJ, Srinivasan R, Metwalli AR, Middelton LA, Peterson J, Yang Y, Linehan WM. Vocke CD, et al. Among authors: yang y. Genes Chromosomes Cancer. 2017 Jun;56(6):484-492. doi: 10.1002/gcc.22452. Epub 2017 Mar 31. Genes Chromosomes Cancer. 2017. PMID: 28196407 Free PMC article.

8

Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc.

Sourbier C, Ricketts CJ, Liao PJ, Matsumoto S, Wei D, Lang M, Railkar R, Yang Y, Wei MH, Agarwal P, Krishna M, Mitchell JB, Trepel JB, Neckers L, Linehan WM. Sourbier C, et al. Among authors: yang y. Sci Rep. 2019 Dec 5;9(1):18409. doi: 10.1038/s41598-019-55003-2. Sci Rep. 2019. PMID: 31804603 Free PMC article.

9

Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway.

Panarsky R, Crooks DR, Lane AN, Yang Y, Cassel TA, Fan TW, Linehan WM, Moscow JA. Panarsky R, et al. Among authors: yang y. Cancer Metab. 2020 Aug 3;8:7. doi: 10.1186/s40170-020-00214-9. eCollection 2020. Cancer Metab. 2020. PMID: 32774853 Free PMC article.

10

Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer.

Crooks DR, Maio N, Lang M, Ricketts CJ, Vocke CD, Gurram S, Turan S, Kim YY, Cawthon GM, Sohelian F, De Val N, Pfeiffer RM, Jailwala P, Tandon M, Tran B, Fan TW, Lane AN, Ried T, Wangsa D, Malayeri AA, Merino MJ, Yang Y, Meier JL, Ball MW, Rouault TA, Srinivasan R, Linehan WM. Crooks DR, et al. Among authors: yang y. Sci Signal. 2021 Jan 5;14(664):eabc4436. doi: 10.1126/scisignal.abc4436. Sci Signal. 2021. PMID: 33402335 Free PMC article.

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