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Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics.
Lechuga-Vieco AV, Latorre-Pellicer A, Johnston IG, Prota G, Gileadi U, Justo-Méndez R, Acín-Pérez R, Martínez-de-Mena R, Fernández-Toro JM, Jimenez-Blasco D, Mora A, Nicolás-Ávila JA, Santiago DJ, Priori SG, Bolaños JP, Sabio G, Criado LM, Ruíz-Cabello J, Cerundolo V, Jones NS, Enríquez JA. Lechuga-Vieco AV, et al. Sci Adv. 2020 Jul 29;6(31):eaba5345. doi: 10.1126/sciadv.aba5345. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32832682 Free PMC article.
Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty.
Lechuga-Vieco AV, Latorre-Pellicer A, Calvo E, Torroja C, Pellico J, Acín-Pérez R, García-Gil ML, Santos A, Bagwan N, Bonzon-Kulichenko E, Magni R, Benito M, Justo-Méndez R, Simon AK, Sánchez-Cabo F, Vázquez J, Ruíz-Cabello J, Enríquez JA. Lechuga-Vieco AV, et al. Among authors: acin perez r. Circulation. 2022 Apr 5;145(14):1084-1101. doi: 10.1161/CIRCULATIONAHA.121.056286. Epub 2022 Mar 3. Circulation. 2022. PMID: 35236094 Free PMC article.
p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1.
Santamans AM, Montalvo-Romeral V, Mora A, Lopez JA, González-Romero F, Jimenez-Blasco D, Rodríguez E, Pintor-Chocano A, Casanueva-Benítez C, Acín-Pérez R, Leiva-Vega L, Duran J, Guinovart JJ, Jiménez-Borreguero J, Enríquez JA, Villlalba-Orero M, Bolaños JP, Aspichueta P, Vázquez J, González-Terán B, Sabio G. Santamans AM, et al. Among authors: acin perez r. PLoS Biol. 2021 Nov 10;19(11):e3001447. doi: 10.1371/journal.pbio.3001447. eCollection 2021 Nov. PLoS Biol. 2021. PMID: 34758018 Free PMC article.
Analyzing electron transport chain supercomplexes.
Acín-Pérez R, Hernansanz-Agustín P, Enríquez JA. Acín-Pérez R, et al. Methods Cell Biol. 2020;155:181-197. doi: 10.1016/bs.mcb.2019.12.002. Epub 2020 Feb 27. Methods Cell Biol. 2020. PMID: 32183958
MKK6 controls T3-mediated browning of white adipose tissue.
Matesanz N, Bernardo E, Acín-Pérez R, Manieri E, Pérez-Sieira S, Hernández-Cosido L, Montalvo-Romeral V, Mora A, Rodríguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Álvarez CV, Marcos M, Enríquez JA, Nogueiras R, Sabio G. Matesanz N, et al. Nat Commun. 2017 Oct 11;8(1):856. doi: 10.1038/s41467-017-00948-z. Nat Commun. 2017. PMID: 29021624 Free PMC article.
Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity.
Acín-Pérez R, Iborra S, Martí-Mateos Y, Cook ECL, Conde-Garrosa R, Petcherski A, Muñoz MDM, Martínez de Mena R, Krishnan KC, Jiménez C, Bolaños JP, Laakso M, Lusis AJ, Shirihai OS, Sancho D, Enríquez JA. Acín-Pérez R, et al. Nat Metab. 2020 Sep;2(9):974-988. doi: 10.1038/s42255-020-00273-8. Epub 2020 Sep 17. Nat Metab. 2020. PMID: 32943786 Free PMC article.
Ablation of the stress protease OMA1 protects against heart failure in mice.
Acin-Perez R, Lechuga-Vieco AV, Del Mar Muñoz M, Nieto-Arellano R, Torroja C, Sánchez-Cabo F, Jiménez C, González-Guerra A, Carrascoso I, Benincá C, Quiros PM, López-Otín C, Castellano JM, Ruíz-Cabello J, Jiménez-Borreguero LJ, Enríquez JA. Acin-Perez R, et al. Sci Transl Med. 2018 Mar 28;10(434):eaan4935. doi: 10.1126/scitranslmed.aan4935. Sci Transl Med. 2018. PMID: 29593106
Na+ controls hypoxic signalling by the mitochondrial respiratory chain.
Hernansanz-Agustín P, Choya-Foces C, Carregal-Romero S, Ramos E, Oliva T, Villa-Piña T, Moreno L, Izquierdo-Álvarez A, Cabrera-García JD, Cortés A, Lechuga-Vieco AV, Jadiya P, Navarro E, Parada E, Palomino-Antolín A, Tello D, Acín-Pérez R, Rodríguez-Aguilera JC, Navas P, Cogolludo Á, López-Montero I, Martínez-Del-Pozo Á, Egea J, López MG, Elrod JW, Ruíz-Cabello J, Bogdanova A, Enríquez JA, Martínez-Ruiz A. Hernansanz-Agustín P, et al. Nature. 2020 Oct;586(7828):287-291. doi: 10.1038/s41586-020-2551-y. Epub 2020 Jul 29. Nature. 2020. PMID: 32728214 Free PMC article.
82 results