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Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics.
Lechuga-Vieco AV, Latorre-Pellicer A, Johnston IG, Prota G, Gileadi U, Justo-Méndez R, Acín-Pérez R, Martínez-de-Mena R, Fernández-Toro JM, Jimenez-Blasco D, Mora A, Nicolás-Ávila JA, Santiago DJ, Priori SG, Bolaños JP, Sabio G, Criado LM, Ruíz-Cabello J, Cerundolo V, Jones NS, Enríquez JA. Lechuga-Vieco AV, et al. Among authors: mora a. Sci Adv. 2020 Jul 29;6(31):eaba5345. doi: 10.1126/sciadv.aba5345. eCollection 2020 Jul. Sci Adv. 2020. PMID: 32832682 Free PMC article.
MKK6 controls T3-mediated browning of white adipose tissue.
Matesanz N, Bernardo E, Acín-Pérez R, Manieri E, Pérez-Sieira S, Hernández-Cosido L, Montalvo-Romeral V, Mora A, Rodríguez E, Leiva-Vega L, Lechuga-Vieco AV, Ruiz-Cabello J, Torres JL, Crespo-Ruiz M, Centeno F, Álvarez CV, Marcos M, Enríquez JA, Nogueiras R, Sabio G. Matesanz N, et al. Among authors: mora a. Nat Commun. 2017 Oct 11;8(1):856. doi: 10.1038/s41467-017-00948-z. Nat Commun. 2017. PMID: 29021624 Free PMC article.
p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.
Matesanz N, Nikolic I, Leiva M, Pulgarín-Alfaro M, Santamans AM, Bernardo E, Mora A, Herrera-Melle L, Rodríguez E, Beiroa D, Caballero A, Martín-García E, Acín-Pérez R, Hernández-Cosido L, Leiva-Vega L, Torres JL, Centeno F, Nebreda AR, Enríquez JA, Nogueiras R, Marcos M, Sabio G. Matesanz N, et al. Among authors: mora a. PLoS Biol. 2018 Jul 6;16(7):e2004455. doi: 10.1371/journal.pbio.2004455. eCollection 2018 Jul. PLoS Biol. 2018. PMID: 29979672 Free PMC article.
p38γ is essential for cell cycle progression and liver tumorigenesis.
Tomás-Loba A, Manieri E, González-Terán B, Mora A, Leiva-Vega L, Santamans AM, Romero-Becerra R, Rodríguez E, Pintor-Chocano A, Feixas F, López JA, Caballero B, Trakala M, Blanco Ó, Torres JL, Hernández-Cosido L, Montalvo-Romeral V, Matesanz N, Roche-Molina M, Bernal JA, Mischo H, León M, Caballero A, Miranda-Saavedra D, Ruiz-Cabello J, Nevzorova YA, Cubero FJ, Bravo J, Vázquez J, Malumbres M, Marcos M, Osuna S, Sabio G. Tomás-Loba A, et al. Among authors: mora a. Nature. 2019 Apr;568(7753):557-560. doi: 10.1038/s41586-019-1112-8. Epub 2019 Apr 10. Nature. 2019. PMID: 30971822
p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1.
Santamans AM, Montalvo-Romeral V, Mora A, Lopez JA, González-Romero F, Jimenez-Blasco D, Rodríguez E, Pintor-Chocano A, Casanueva-Benítez C, Acín-Pérez R, Leiva-Vega L, Duran J, Guinovart JJ, Jiménez-Borreguero J, Enríquez JA, Villlalba-Orero M, Bolaños JP, Aspichueta P, Vázquez J, González-Terán B, Sabio G. Santamans AM, et al. Among authors: mora a. PLoS Biol. 2021 Nov 10;19(11):e3001447. doi: 10.1371/journal.pbio.3001447. eCollection 2021 Nov. PLoS Biol. 2021. PMID: 34758018 Free PMC article.
DIDO is necessary for the adipogenesis that promotes diet-induced obesity.
García-López MÁ, Mora A, Corrales P, Pons T, Sánchez de Diego A, Talavera Gutiérrez A, van Wely KHM, Medina-Gómez G, Sabio G, Martínez-A C, Fischer T. García-López MÁ, et al. Among authors: mora a. Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2300096121. doi: 10.1073/pnas.2300096121. Epub 2024 Jan 9. Proc Natl Acad Sci U S A. 2024. PMID: 38194457
MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension.
Santamans AM, Cicuéndez B, Mora A, Villalba-Orero M, Rajlic S, Crespo M, Vo P, Jerome M, Macías Á, López JA, Leiva M, Rocha SF, León M, Rodríguez E, Leiva L, Pintor Chocano A, García Lunar I, García-Álvarez A, Hernansanz-Agustín P, Peinado VI, Barberá JA, Ibañez B, Vázquez J, Spinelli JB, Daiber A, Oliver E, Sabio G. Santamans AM, et al. Among authors: mora a. Sci Adv. 2024 Jan 19;10(3):eadk6524. doi: 10.1126/sciadv.adk6524. Epub 2024 Jan 19. Sci Adv. 2024. PMID: 38241373 Free PMC article.
970 results