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Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo.
Sampson AK, Irvine JC, Shihata WA, Dragoljevic D, Lumsden N, Huet O, Barnes T, Unger T, Steckelings UM, Jennings GL, Widdop RE, Chin-Dusting JP. Sampson AK, et al. Among authors: steckelings um. Br J Pharmacol. 2016 Feb;173(4):729-40. doi: 10.1111/bph.13063. Epub 2015 Jun 29. Br J Pharmacol. 2016. PMID: 25560767 Free PMC article.
Anti-fibrotic mechanisms of angiotensin AT2 -receptor stimulation.
Sumners C, Peluso AA, Haugaard AH, Bertelsen JB, Steckelings UM. Sumners C, et al. Among authors: steckelings um. Acta Physiol (Oxf). 2019 Sep;227(1):e13280. doi: 10.1111/apha.13280. Epub 2019 Apr 29. Acta Physiol (Oxf). 2019. PMID: 30957953 Review.
AT2R stimulation with C21 prevents arterial stiffening and endothelial dysfunction in the abdominal aorta from mice fed a high-fat diet.
González-Blázquez R, Alcalá M, Cárdenas-Rebollo JM, Viana M, Steckelings UM, Boisvert WA, Unger T, Fernández-Alfonso MS, Somoza B, Gil-Ortega M. González-Blázquez R, et al. Among authors: steckelings um. Clin Sci (Lond). 2021 Dec 22;135(24):2763-2780. doi: 10.1042/CS20210971. Clin Sci (Lond). 2021. PMID: 34854902
Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.
Bruce E, Shenoy V, Rathinasabapathy A, Espejo A, Horowitz A, Oswalt A, Francis J, Nair A, Unger T, Raizada MK, Steckelings UM, Sumners C, Katovich MJ. Bruce E, et al. Among authors: steckelings um. Br J Pharmacol. 2015 May;172(9):2219-31. doi: 10.1111/bph.13044. Epub 2015 Feb 27. Br J Pharmacol. 2015. PMID: 25522140 Free PMC article.
122 results