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A living WHO guideline on drugs for covid-19.
Agarwal A, Hunt B, Stegemann M, Rochwerg B, Lamontagne F, Siemieniuk RA, Agoritsas T, Askie L, Lytvyn L, Leo YS, Macdonald H, Zeng L, Alhadyan A, Muna A, Amin W, da Silva ARA, Aryal D, Barragan FAJ, Bausch FJ, Burhan E, Calfee CS, Cecconi M, Chacko B, Chanda D, Dat VQ, De Sutter A, Du B, Freedman S, Geduld H, Gee P, Haider M, Gotte M, Harley N, Hashimi M, Hui D, Ismail M, Jehan F, Kabra SK, Kanda S, Kim YJ, Kissoon N, Krishna S, Kuppalli K, Kwizera A, Lado Castro-Rial M, Lisboa T, Lodha R, Mahaka I, Manai H, Mendelson M, Migliori GB, Mino G, Nsutebu E, Peter J, Preller J, Pshenichnaya N, Qadir N, Ranganathan SS, Relan P, Rylance J, Sabzwari S, Sarin R, Shankar-Hari M, Sharland M, Shen Y, Souza JP, Swanstrom R, Tshokey T, Ugarte S, Uyeki T, Evangelina VC, Venkatapuram S, Vuyiseka D, Wijewickrama A, Tran L, Zeraatkar D, Bartoszko JJ, Ge L, Brignardello-Petersen R, Owen A, Guyatt G, Diaz J, Kawano-Dourado L, Jacobs M, Vandvik PO. Agarwal A, et al. Among authors: gotte m. BMJ. 2020 Sep 4;370:m3379. doi: 10.1136/bmj.m3379. BMJ. 2020. PMID: 32887691 Updated.
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms.
Stevens LJ, Pruijssers AJ, Lee HW, Gordon CJ, Tchesnokov EP, Gribble J, George AS, Hughes TM, Lu X, Li J, Perry JK, Porter DP, Cihlar T, Sheahan TP, Baric RS, Götte M, Denison MR. Stevens LJ, et al. Among authors: gotte m. Sci Transl Med. 2022 Aug 3;14(656):eabo0718. doi: 10.1126/scitranslmed.abo0718. Epub 2022 Aug 3. Sci Transl Med. 2022. PMID: 35482820 Free PMC article.
Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit.
Hall MD, Anderson JM, Anderson A, Baker D, Bradner J, Brimacombe KR, Campbell EA, Corbett KS, Carter K, Cherry S, Chiang L, Cihlar T, de Wit E, Denison M, Disney M, Fletcher CV, Ford-Scheimer SL, Götte M, Grossman AC, Hayden FG, Hazuda DJ, Lanteri CA, Marston H, Mesecar AD, Moore S, Nwankwo JO, O'Rear J, Painter G, Singh Saikatendu K, Schiffer CA, Sheahan TP, Shi PY, Smyth HD, Sofia MJ, Weetall M, Weller SK, Whitley R, Fauci AS, Austin CP, Collins FS, Conley AJ, Davis MI. Hall MD, et al. Among authors: gotte m. J Infect Dis. 2021 Jul 15;224(Supplement_1):S1-S21. doi: 10.1093/infdis/jiab305. J Infect Dis. 2021. PMID: 34111271 Free PMC article.
Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases.
Lo MK, Albariño CG, Perry JK, Chang S, Tchesnokov EP, Guerrero L, Chakrabarti A, Shrivastava-Ranjan P, Chatterjee P, McMullan LK, Martin R, Jordan R, Götte M, Montgomery JM, Nichol ST, Flint M, Porter D, Spiropoulou CF. Lo MK, et al. Among authors: gotte m. Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26946-26954. doi: 10.1073/pnas.2012294117. Epub 2020 Oct 7. Proc Natl Acad Sci U S A. 2020. PMID: 33028676 Free PMC article.
Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template.
Gordon CJ, Tchesnokov EP, Schinazi RF, Götte M. Gordon CJ, et al. Among authors: gotte m. J Biol Chem. 2021 Jul;297(1):100770. doi: 10.1016/j.jbc.2021.100770. Epub 2021 May 11. J Biol Chem. 2021. PMID: 33989635 Free PMC article.
519 results