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Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer.
Elife. 2020 Sep 8;9:e58204. doi: 10.7554/eLife.58204.
Elife. 2020.
PMID: 32897190
Free PMC article.
In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies.
Sealover NE, Theard PL, Hughes JM, Linke AJ, Daley BR, Kortum RL.
Sealover NE, et al. Among authors: linke aj.
bioRxiv [Preprint]. 2023 Jun 28:2023.01.27.525958. doi: 10.1101/2023.01.27.525958.
bioRxiv. 2023.
PMID: 36747633
Free PMC article.
Updated.
Preprint.
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SOS2 regulates the threshold of mutant EGFR-dependent oncogenesis.
Theard PL, Linke AJ, Sealover NE, Daley BR, Yang J, Cox K, Kortum RL.
Theard PL, et al. Among authors: linke aj.
bioRxiv [Preprint]. 2023 Jun 29:2023.01.20.524989. doi: 10.1101/2023.01.20.524989.
bioRxiv. 2023.
PMID: 37425733
Free PMC article.
Updated.
Preprint.
Item in Clipboard
SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma.
Theard PL, Linke AJ, Sealover NE, Daley BR, Yang J, Cox K, Kortum RL.
Theard PL, et al. Among authors: linke aj.
Mol Oncol. 2024 Mar;18(3):641-661. doi: 10.1002/1878-0261.13564. Epub 2024 Jan 18.
Mol Oncol. 2024.
PMID: 38073064
Free PMC article.
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SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma.
Daley BR, Sealover NE, Sheffels E, Hughes JM, Gerlach D, Hofmann MH, Kostyrko K, Mair B, Linke A, Beckley Z, Frank A, Dalgard C, Kortum RL.
Daley BR, et al.
bioRxiv [Preprint]. 2023 Dec 15:2023.12.07.570642. doi: 10.1101/2023.12.07.570642.
bioRxiv. 2023.
PMID: 38106234
Free PMC article.
Preprint.
Item in Clipboard
In situ modeling of acquired resistance to RTK/RAS-pathway-targeted therapies.
Sealover NE, Theard PT, Hughes JM, Linke AJ, Daley BR, Kortum RL.
Sealover NE, et al. Among authors: linke aj.
iScience. 2023 Dec 11;27(1):108711. doi: 10.1016/j.isci.2023.108711. eCollection 2024 Jan 19.
iScience. 2023.
PMID: 38226159
Free PMC article.
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STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer.
Lefler JE, MarElia-Bennett CB, Thies KA, Hildreth BE 3rd, Sharma SM, Pitarresi JR, Han L, Everett C, Koivisto C, Cuitino MC, Timmers CD, O'Quinn E, Parrish M, Romeo MJ, Linke AJ, Hobbs GA, Leone G, Guttridge DC, Zimmers TA, Lesinski GB, Ostrowski MC.
Lefler JE, et al. Among authors: linke aj.
Life Sci Alliance. 2022 Jul 8;5(11):e202201460. doi: 10.26508/lsa.202201460. Print 2022 Nov.
Life Sci Alliance. 2022.
PMID: 35803738
Free PMC article.
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