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Highly infectious prions are not directly neurotoxic.
Benilova I, Reilly M, Terry C, Wenborn A, Schmidt C, Marinho AT, Risse E, Al-Doujaily H, Wiggins De Oliveira M, Sandberg MK, Wadsworth JDF, Jat PS, Collinge J. Benilova I, et al. Among authors: schmidt c. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23815-23822. doi: 10.1073/pnas.2007406117. Epub 2020 Sep 8. Proc Natl Acad Sci U S A. 2020. PMID: 32900920 Free PMC article.
A systematic investigation of production of synthetic prions from recombinant prion protein.
Schmidt C, Fizet J, Properzi F, Batchelor M, Sandberg MK, Edgeworth JA, Afran L, Ho S, Badhan A, Klier S, Linehan JM, Brandner S, Hosszu LL, Tattum MH, Jat P, Clarke AR, Klöhn PC, Wadsworth JD, Jackson GS, Collinge J. Schmidt C, et al. Open Biol. 2015 Dec;5(12):150165. doi: 10.1098/rsob.150165. Open Biol. 2015. PMID: 26631378 Free PMC article.
Physical, chemical and kinetic factors affecting prion infectivity.
Properzi F, Badhan A, Klier S, Schmidt C, Klöhn PC, Wadsworth JD, Clarke AR, Jackson GS, Collinge J. Properzi F, et al. Among authors: schmidt c. Prion. 2016 May 3;10(3):251-61. doi: 10.1080/19336896.2016.1181250. Prion. 2016. PMID: 27282252 Free PMC article.
Prion protein monoclonal antibody (PRN100) therapy for Creutzfeldt-Jakob disease: evaluation of a first-in-human treatment programme.
Mead S, Khalili-Shirazi A, Potter C, Mok T, Nihat A, Hyare H, Canning S, Schmidt C, Campbell T, Darwent L, Muirhead N, Ebsworth N, Hextall P, Wakeling M, Linehan J, Libri V, Williams B, Jaunmuktane Z, Brandner S, Rudge P, Collinge J. Mead S, et al. Among authors: schmidt c. Lancet Neurol. 2022 Apr;21(4):342-354. doi: 10.1016/S1474-4422(22)00082-5. Lancet Neurol. 2022. PMID: 35305340
Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD.
Wang Y, Ullah MA, Waltner OG, Bhise SS, Ensbey KS, Schmidt CR, Legg SR, Sekiguchi T, Nelson EL, Kuns RD, Nemychenkov NS, Atilla E, Yeh AC, Takahashi S, Boiko JR, Varelias A, Blazar BR, Koyama M, Minnie SA, Clouston AD, Furlan SN, Zhang P, Hill GR. Wang Y, et al. Among authors: schmidt cr. J Clin Invest. 2024 Jun 3;134(11):e170125. doi: 10.1172/JCI170125. J Clin Invest. 2024. PMID: 38828727
5,929 results