Pancreatic β-cell Na+ channels control global Ca2+ signaling and oxidative metabolism by inducing Na+ and Ca2+ responses that are propagated into mitochondria.
Nita II, Hershfinkel M, Kantor C, Rutter GA, Lewis EC, Sekler I.
Nita II, et al. Among authors: sekler i.
FASEB J. 2014 Aug;28(8):3301-12. doi: 10.1096/fj.13-248161. Epub 2014 Apr 9.
FASEB J. 2014.
PMID: 24719357
Free PMC article.
Our results show that communication of the Na(+) channels with mitochondria shape both global Ca(2+) and metabolism signals linked to insulin secretion in beta cells.- Nita, I. I., Hershfinkel, M., Kantor, C., Rutter, G. A., Lewis, E. C., Sekler, I. .. …
Our results show that communication of the Na(+) channels with mitochondria shape both global Ca(2+) and metabolism signals linked to insuli …