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Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy.
Mastellos DC, Pires da Silva BGP, Fonseca BAL, Fonseca NP, Auxiliadora-Martins M, Mastaglio S, Ruggeri A, Sironi M, Radermacher P, Chrysanthopoulou A, Skendros P, Ritis K, Manfra I, Iacobelli S, Huber-Lang M, Nilsson B, Yancopoulou D, Connolly ES, Garlanda C, Ciceri F, Risitano AM, Calado RT, Lambris JD. Mastellos DC, et al. Among authors: garlanda c. Clin Immunol. 2020 Nov;220:108598. doi: 10.1016/j.clim.2020.108598. Epub 2020 Sep 19. Clin Immunol. 2020. PMID: 32961333 Free PMC article.
Pathogen recognition by the long pentraxin PTX3.
Moalli F, Jaillon S, Inforzato A, Sironi M, Bottazzi B, Mantovani A, Garlanda C. Moalli F, et al. Among authors: garlanda c. J Biomed Biotechnol. 2011;2011:830421. doi: 10.1155/2011/830421. Epub 2011 Jun 2. J Biomed Biotechnol. 2011. PMID: 21716666 Free PMC article. Review.
PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.
Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, Greco C, Feruglio F, Molgora M, Laface I, Tartari S, Doni A, Pasqualini F, Barbati E, Basso G, Galdiero MR, Nebuloni M, Roncalli M, Colombo P, Laghi L, Lambris JD, Jaillon S, Garlanda C, Mantovani A. Bonavita E, et al. Among authors: garlanda c. Cell. 2015 Feb 12;160(4):700-714. doi: 10.1016/j.cell.2015.01.004. Cell. 2015. PMID: 25679762 Free article.
Complement as a target in COVID-19?
Risitano AM, Mastellos DC, Huber-Lang M, Yancopoulou D, Garlanda C, Ciceri F, Lambris JD. Risitano AM, et al. Among authors: garlanda c. Nat Rev Immunol. 2020 Jun;20(6):343-344. doi: 10.1038/s41577-020-0320-7. Epub 2020 Apr 23. Nat Rev Immunol. 2020. PMID: 32327719 Free PMC article.
The first case of COVID-19 treated with the complement C3 inhibitor AMY-101.
Mastaglio S, Ruggeri A, Risitano AM, Angelillo P, Yancopoulou D, Mastellos DC, Huber-Lang M, Piemontese S, Assanelli A, Garlanda C, Lambris JD, Ciceri F. Mastaglio S, et al. Among authors: garlanda c. Clin Immunol. 2020 Jun;215:108450. doi: 10.1016/j.clim.2020.108450. Epub 2020 Apr 29. Clin Immunol. 2020. PMID: 32360516 Free PMC article.
Author Correction: Complement as a target in COVID-19?
Risitano AM, Mastellos DC, Huber-Lang M, Yancopoulou D, Garlanda C, Ciceri F, Lambris JD. Risitano AM, et al. Among authors: garlanda c. Nat Rev Immunol. 2020 Jul;20(7):448. doi: 10.1038/s41577-020-0366-6. Nat Rev Immunol. 2020. PMID: 32533108 Free PMC article.
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19.
Brunetta E, Folci M, Bottazzi B, De Santis M, Gritti G, Protti A, Mapelli SN, Bonovas S, Piovani D, Leone R, My I, Zanon V, Spata G, Bacci M, Supino D, Carnevale S, Sironi M, Davoudian S, Peano C, Landi F, Di Marco F, Raimondi F, Gianatti A, Angelini C, Rambaldi A, Garlanda C, Ciccarelli M, Cecconi M, Mantovani A. Brunetta E, et al. Among authors: garlanda c. Nat Immunol. 2021 Jan;22(1):19-24. doi: 10.1038/s41590-020-00832-x. Epub 2020 Nov 18. Nat Immunol. 2021. PMID: 33208929 Free article.
Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression.
Magrini E, Di Marco S, Mapelli SN, Perucchini C, Pasqualini F, Donato A, Guevara Lopez ML, Carriero R, Ponzetta A, Colombo P, Cananzi F, Supino D, Reis ES, Peano C, Inforzato A, Jaillon S, Doni A, Lambris JD, Mantovani A, Garlanda C. Magrini E, et al. Among authors: garlanda c. Nat Cancer. 2021 Feb;2(2):218-232. doi: 10.1038/s43018-021-00173-0. Epub 2021 Feb 18. Nat Cancer. 2021. PMID: 34505065 Free PMC article.
Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules.
Stravalaci M, Pagani I, Paraboschi EM, Pedotti M, Doni A, Scavello F, Mapelli SN, Sironi M, Perucchini C, Varani L, Matkovic M, Cavalli A, Cesana D, Gallina P, Pedemonte N, Capurro V, Clementi N, Mancini N, Invernizzi P, Bayarri-Olmos R, Garred P, Rappuoli R, Duga S, Bottazzi B, Uguccioni M, Asselta R, Vicenzi E, Mantovani A, Garlanda C. Stravalaci M, et al. Among authors: garlanda c. Nat Immunol. 2022 Feb;23(2):275-286. doi: 10.1038/s41590-021-01114-w. Epub 2022 Jan 31. Nat Immunol. 2022. PMID: 35102342
253 results